Krebs cycle: activators, inhibitors and their roles in the modulation of carcinogenesis

A Gasmi, M Peana, M Arshad, M Butnariu… - Archives of …, 2021 - Springer
A fundamental metabolic feature of cancerous tissues is high glucose consumption. The rate
of glucose consumption in a cancer cell can be 10–15 times higher than in normal cells …

Pleiotropic effects of alpha-ketoglutarate as a potential anti-ageing agent

MM Bayliak, VI Lushchak - Ageing research reviews, 2021 - Elsevier
An intermediate of tricarboxylic acid cycle alpha-ketoglutarate (AKG) is involved in
pleiotropic metabolic and regulatory pathways in the cell, including energy production …

Oxidative stress‐alleviating strategies to improve recombinant protein production in CHO cells

V Chevallier, MR Andersen… - Biotechnology and …, 2020 - Wiley Online Library
Large scale biopharmaceutical production of biologics relies on the overexpression of
foreign proteins by cells cultivated in stirred tank bioreactors. It is well recognized and …

Redox rebalance against genetic perturbations and modulation of central carbon metabolism by the oxidative stress regulation

K Shimizu, Y Matsuoka - Biotechnology advances, 2019 - Elsevier
The micro-aerophilic organisms and aerobes as well as yeast and higher organisms have
evolved to gain energy through respiration (via oxidative phosphorylation), thereby enabling …

Effects of in ovo injection of α-ketoglutaric acid on hatchability, growth, plasma metabolites, and antioxidant status of broilers

V Gupta, CM Ncho, A Goel, CM Jeong, YH Choi - Antioxidants, 2022 - mdpi.com
Recently, α-ketoglutaric acid (AKG) has gained importance as an antioxidant. Its dietary
supplementation in animals and humans has proved beneficial. Moreover, an extensive …

Prevention of oxidative stress by α-ketoglutarate via activation of CAR signaling and modulation of the expression of key antioxidant-associated targets in vivo and in …

L He, J Wu, W Tang, X Zhou, Q Lin, F Luo… - Journal of agricultural …, 2018 - ACS Publications
α-Ketoglutarate (AKG) can act as an antioxidant both in vitro and in vivo. However, the
mechanisms of the protective effects of AKG are still not well understood. We evaluated the …

Extraction, purification and antioxidation of a polysaccharide from Fritillaria unibracteata var. wabuensis

F Pan, TJ Su, Y Liu, K Hou, C Chen, W Wu - International Journal of …, 2018 - Elsevier
Rich polysaccharides were directly observed in the bulbs of Fritillaria unibracteata var.
wabuensis (FUW) using the periodic acid–Schiff (PAS) method and microexamination. An …

Entamoeba histolytica—Gut Microbiota Interaction: More Than Meets the Eye

S Ankri - Microorganisms, 2021 - mdpi.com
Amebiasis is a disease caused by the unicellular parasite Entamoeba histolytica. In most
cases, the infection is asymptomatic but when symptomatic, the infection can cause …

[HTML][HTML] mTOR/α-ketoglutarate-mediated signaling pathways in the context of brain neurodegeneration and neuroprotection

O Kostiuchenko, I Lushnikova, M Kowalczyk, G Skibo - BBA advances, 2022 - Elsevier
Cerebral disorders are largely associated with impaired cellular metabolism, despite the
regulatory mechanisms designed to ensure cell viability and adequate brain function …

Low temperature modulates the carbon allocation in different metabolic pathways to improve the tolerance of Arctic Chlorella to high light stress

T Wang, M Gao, H Song, C Wang, M He - Algal Research, 2024 - Elsevier
Polar microalgae, renowned for their exceptional adaptability in extreme environments, are
vital for carbon fixation and nutrient cycling. To understand their metabolic resilience under …