The life sciences are currently being transformed by an unprecedented wave of
developments in molecular analysis, which include important advances in instrumental …

Metabolomics is the comprehensive assessment of endogenous metabolites and attempts to
systematically identify and quantify metabolites from a biological sample. Small-molecule …

Anorexia nervosa (AN) is an eating disorder with a high mortality. About 95% of cases are
women and it has a population prevalence of about 1%, but evidence-based treatment is …

Background & aims Recent experimental models and epidemiological studies suggest that
specific environmental contaminants (ECs) contribute to the initiation and pathology of non …

Insulin resistance is a forerunner state of ischaemic cardiovascular disease and type 2
diabetes. Here we show how the human gut microbiome impacts the serum metabolome …

Colonization of the fetal and infant gut microbiome results in dynamic changes in diversity,
which can impact disease susceptibility. To examine the relationship between human gut …

Bile acids are synthesized from cholesterol in the liver and further metabolized by the gut
microbiota into secondary bile acids. Bile acid synthesis is under negative feedback control …

Background & Aims Recent data in mice have identified de novo ceramide synthesis as the
key mediator of hepatic insulin resistance (IR) that in humans characterizes increases in …

Complex metabolic disruption is a crucial aspect of the pathophysiology of traumatic brain
injury (TBI). Associations between this and systemic metabolism and their potential …

Metabolomics offers a revolutionary framework for phenotyping individuals at a molecular
level that is needed for new breakthroughs in cell biology and personalized medicine. 1− 3 …