The evolving landscape of PCSK9 inhibition in cancer
PP Oza, K Kashfi - European journal of pharmacology, 2023 - Elsevier
Cancer is a disease with a significant global burden in terms of premature mortality, loss of
productivity, healthcare expenditures, and impact on mental health. Recent decades have …
productivity, healthcare expenditures, and impact on mental health. Recent decades have …
PCSK9 in metabolism and diseases
A Ajoolabady, D Pratico, M Mazidi, IG Davies, GYH Lip… - Metabolism, 2024 - Elsevier
PCSK9 is a serine protease that regulates plasma levels of low-density lipoprotein (LDL)
and cholesterol by mediating the endolysosomal degradation of LDL receptor (LDLR) in the …
and cholesterol by mediating the endolysosomal degradation of LDL receptor (LDLR) in the …
A retrospective study on the role of metformin in colorectal cancer liver metastases
Colorectal cancer liver metastases (CRCLMs) have two main histopathological growth
patterns (HPGs): desmoplastic (DHGP) and replacement (RHGP). The vascularization in …
patterns (HPGs): desmoplastic (DHGP) and replacement (RHGP). The vascularization in …
Inhibition of proprotein convertase subtilisin-like kexin type 9 (PCSK9) potentiates anti-angiogenic therapy in colorectal cancer liver metastases
Colorectal cancer liver metastatic (CRCLM) tumours present as two main histopathological
growth patterns (HGPs) including desmoplastic HGP (DHGP) and replacement HGP …
growth patterns (HGPs) including desmoplastic HGP (DHGP) and replacement HGP …
Dysregulation of Cholesterol Homeostasis in Ovarian Cancer
Z Qusairy, A Gangloff, SOA Leung - Current Oncology, 2023 - mdpi.com
Cholesterol plays an essential role in maintaining the rigidity of cell membranes and signal
transduction. Various investigations confirmed empirically that the dysregulation of …
transduction. Various investigations confirmed empirically that the dysregulation of …
Vitamin D supplementation improves the prognosis of patients with colorectal cancer liver metastases
M Rada, L Krzywon, A Kapelanski-Lamoureux, D Kim… - medRxiv, 2022 - medrxiv.org
Colorectal cancer liver metastasis (CRCLM) is one of the deadliest cancers. CRCLM
tumours have two distinct histopathological growth patterns (HGPs) including desmoplastic …
tumours have two distinct histopathological growth patterns (HGPs) including desmoplastic …
International Biospecimen Sourcing Platform: A Key Player in Advancing Health Research and Drug Discovery
The field of biobanking human biospecimens has evolved significantly, transitioning from the
basic, often poorly documented collection of clinical leftovers kept privately to well-organized …
basic, often poorly documented collection of clinical leftovers kept privately to well-organized …