Hemorrhagic transformation of ischemic strokes

KB Kovács, V Bencs, L Hudák, L Oláh… - International Journal of …, 2023 - mdpi.com
Ischemic stroke, resulting from insufficient blood supply to the brain, is among the leading
causes of death and disability worldwide. A potentially severe complication of the disease …

Vitamin D as a Modulator of Neuroinflammation: Implications for Brain Health

SG Menéndez, W Manucha - Current Pharmaceutical Design, 2024 - ingentaconnect.com
Neuroinflammation represents a critical immune response within the brain, playing a pivotal
role in defense against injury and infection. However, when this response becomes chronic …

FNDC5/Irisin protects neurons through Caspase3 and Bax pathways

QX Zhang, LJ Zhang, N Zhao… - Cell Biochemistry and …, 2024 - Wiley Online Library
Irisin is a glycosylated protein formed from the hydrolysis of fibronectin type III domain‐
containing protein 5 (FNDC5). Recent studies have demonstrated that FNDC5/Irisin is …

ICAM-1 Deletion Using CRISPR/Cas9 Protects the Brain from Traumatic Brain Injury-Induced Inflammatory Leukocyte Adhesion and Transmigration Cascades by …

BB Saikia, S Bhowmick, A Malat, MRP Rani… - Journal of …, 2024 - Soc Neuroscience
Intercellular adhesion molecule-1 (ICAM-1) is identified as an initiator of neuroinflammatory
responses that lead to neurodegeneration and cognitive and sensory–motor deficits in …

Sex-dependent temporal changes in astrocyte-vessel interactions following diffuse traumatic brain injury in rats

Z Sabetta, G Krishna, T Curry-Koski, M Lopez… - Frontiers in …, 2024 - frontiersin.org
Traumatic brain injury (TBI) is associated with diffuse axonal injury (DAI), a primary
pathology linked to progressive neurodegeneration and neuroinflammation, including …

Evidence for interictal blood–brain barrier dysfunction in people with epilepsy

JT Reiter, F Schulte, T Bauer, B David, C Endler… - …, 2024 - Wiley Online Library
Objective Interictal blood–brain barrier dysfunction in chronic epilepsy has been
demonstrated in animal models and pathological specimens. Ictal blood–brain barrier …

Interictal blood–brain barrier dysfunction in piriform cortex of people with epilepsy

F Schulte, JT Reiter, T Bauer, J Taube… - Annals of Clinical …, 2024 - Wiley Online Library
Objective The piriform cortex is considered to be highly epileptogenic. Its resection during
epilepsy surgery is a predictor for postoperative seizure freedom in temporal lobe epilepsy …

Study on the metabolic effects of hexavalent chromium [Cr (VI)] on rat astrocytes using un-targeted metabolomics

H Tang, K Li, L Lin, W Wang, W Jian - Frontiers in Molecular …, 2024 - frontiersin.org
Introduction: Hexavalent chromium [Cr (VI)] has been identified as a human carcinogen and
environmental pollutant capable of affecting multiple systems in the human body. However …

Association between fibrinogen‐to‐albumin ratio and functional prognosis of 3 months in patients with acute ischemic stroke after intravenous thrombolysis

X Chen, X Xu, Y Li, F Liu, B Zhang, L Zuo - Brain and Behavior, 2024 - Wiley Online Library
Background The presence of high fibrinogen and low albumin levels in serum is associated
with a negative prognosis in acute ischemic stroke (AIS). Fibrinogen‐to‐albumin ratio (FAR) …