To inform optimal approaches for detecting anal precancers, we performed a systematic
review and meta‐analysis of the diagnostic accuracy of anal cancer screening tests in …

Objective The incidence of anal cancer is higher in women than men in the general
population and has been increasing for several decades. Similar to cervical cancer, most …

Background With the advent of primary human papillomavirus testing followed by cytology
for cervical cancer screening, visual interpretation of cytology slides remains the last …

The second factor that has resulted in a paradigm shift in understanding the etiology of anal
cancer is the discovery that the human papilloma virus (HPV), especially HPV serotypes 16 …

Anal cancer incidence and mortality have been increasing over the past decade. Although
the incidence in the general population remains low, it is much higher in certain subgroups …

Human papillomaviruses (HPVs) are the necessary cause of most cervical cancers, a large
proportion of other anogenital cancers, and a subset of oropharyngeal cancers. The …

Objective: To quantify incidence of, and risk factors for, progression to and spontaneous
regression of high-grade anal squamous intraepithelial lesions (ASILs). Design …

This chapter provides an overview of anal cancer and contemporary approaches for anal
precancer detection, beginning with a discussion of the biology and natural history of anal …

Background Screening strategies for high-risk human papillomavirus (hrHPV)-associated
anal cancer are evolving. Herein, we compare anal cytology to hrHPV DNA testing and 2 …

Background Anal cancer prevention has two critical points: the incidence rate is several fold
higher for some groups, such as people living with human immunodeficiency virus (HIV) and …