Apoptotic cells have long been considered as intrinsically tolerogenic or unable to elicit
immune responses specific for dead cell-associated antigens. However, multiple stimuli can …

Depending on the initiating stimulus, cancer cell death can be immunogenic or
nonimmunogenic. Immunogenic cell death (ICD) involves changes in the composition of the …

Overcoming the resistance to apoptosis and immunosuppression of tumor cells is a
significant challenge in augmenting the effect of cancer immunotherapy. Pyroptosis, a lytic …

Immunogenic cell death (ICD) provides momentous theoretical principle for modern cancer
immunotherapy. However, the currently available ICD inducers are still very limited and …

Immunogenic cell death (ICD) based on endoplasmic reticulum (ER) stress has been widely
studied as the fundamentals of cancer immunotherapy. However, the currently available ICD …

The combination of immunogenic cell death (ICD) induction and immune checkpoint
blockade has emerged as a major direction of cancer immunotherapy. Among currently …

Inefficient T cell migration is a major limitation of cancer immunotherapy. Targeted activation
of the tumor microenvironment may overcome this barrier. We demonstrate that neoadjuvant …

Focused oxidative stress of the specific organelles (eg, endoplasmic reticulum (ER) and
mitochondrion) of cancer cells can boost the immunogenic cell death (ICD) effect for cancer …

Lipid droplet (LD) accumulation is a now well-recognised hallmark of cancer. However, the
significance of LD accumulation in colorectal cancer (CRC) biology is incompletely …

Cancer immunotherapy attempts to harness the power and specificity of the immune system
to treat tumours. The molecular identification of human cancer-specific antigens has allowed …