Multidrug resistance in cancer: role of ATP–dependent transporters

MM Gottesman, T Fojo, SE Bates - Nature reviews cancer, 2002 - nature.com
Chemotherapeutics are the most effective treatment for metastatic tumours. However, the
ability of cancer cells to become simultaneously resistant to different drugs—a trait known as …

Exploring the cellular accumulation of metal complexes

CA Puckett, RJ Ernst, JK Barton - Dalton Transactions, 2010 - pubs.rsc.org
Transition metal complexes offer great potential as diagnostic and therapeutic agents, and a
growing number of biological applications have been explored. To be effective, these …

Choroid plexus epithelial expression of MDR1 P glycoprotein and multidrug resistance-associated protein contribute to the blood–cerebrospinal-fluid drug …

VV Rao, JL Dahlheimer, ME Bardgett… - Proceedings of the …, 1999 - National Acad Sciences
The blood–brain barrier and a blood–cerebrospinal-fluid (CSF) barrier function together to
isolate the brain from circulating drugs, toxins, and xenobiotics. The blood–CSF drug …

Multidrug resistance transporters and modulation

B Tan, D Piwnica-Worms, L Ratner - Current opinion in oncology, 2000 - journals.lww.com
Multidrug resistance (MDR), whereby tumor cells simultaneously possess intrinsic or
acquired cross-resistance to diverse chemotherapeutic agents, hampers the effective …

ATP binding cassette transporters and drug resistance in breast cancer.

F Leonessa, R Clarke - Endocrine-related cancer, 2003 - erc.bioscientifica.com
Resistance to chemotherapy is a critical issue in the management of breast cancer patients.
The nature of clinical drug resistance is likely to be multifactorial. However, in the last …

ABC transporters during epilepsy and mechanisms underlying multidrug resistance in refractory epilepsy

A Lazarowski, L Czornyj, F Lubienieki, E Girardi… - …, 2007 - Wiley Online Library
It is estimated 20–25% of the epileptic patients fails to achieve good control with the different
antiepileptic drugs (AEDs) treatments, developing refractory epilepsy (RE). Discovered first …

Imaging P‐glycoprotein transport activity at the human blood‐brain barrier with positron emission tomography

L Sasongko, JM Link, M Muzi… - Clinical …, 2005 - Wiley Online Library
Background Numerous knockout mouse studies have revealed that P‐glycoprotein (P‐gp)
significantly limits drug distribution across the mouse blood‐brain barrier (BBB). To …

Pharmacokinetic and pharmacodynamic implications of P‐glycoprotein modulation

CJ Matheny, MW Lamb, KLR Brouwer… - … : The Journal of …, 2001 - Wiley Online Library
P‐glycoprotein (P‐gp) is a cell membrane—associated protein that transports a variety of
drug substrates. Although P‐gp has been studied extensively as a mediator of multidrug …

Role of PSMA-ligands imaging in renal cell carcinoma management: current status and future perspectives

L Urso, A Castello, GC Rocca, F Lancia… - Journal of Cancer …, 2022 - Springer
Background Renal masses detection is continually increasing worldwide, with Renal Cell
Carcinoma (RCC) accounting for approximately 90% of all renal cancers and remaining one …

Drug transporters in the lung—do they play a role in the biopharmaceutics of inhaled drugs?

C Bosquillon - Journal of pharmaceutical sciences, 2010 - Elsevier
The role of transporters in drug absorption, distribution and elimination processes as well as
in drug–drug interactions is increasingly being recognised. Although the lungs express high …