Antisense technology: A review
ST Crooke, XH Liang, BF Baker, RM Crooke - Journal of Biological …, 2021 - ASBMB
Antisense technology is beginning to deliver on the broad promise of the technology. Ten
RNA-targeted drugs including eight single-strand antisense drugs (ASOs) and two double …
RNA-targeted drugs including eight single-strand antisense drugs (ASOs) and two double …
Phosphorothioate modified oligonucleotide–protein interactions
ST Crooke, TA Vickers, X Liang - Nucleic acids research, 2020 - academic.oup.com
Antisense oligonucleotides (ASOs) interact with target RNAs via hybridization to modulate
gene expression through different mechanisms. ASO therapeutics are chemically modified …
gene expression through different mechanisms. ASO therapeutics are chemically modified …
Adenine oligomer directed synthesis of chiral gold nanoparticles
Precise control of morphology and optical response of 3-dimensional chiral nanoparticles
remain as a significant challenge. This work demonstrates chiral gold nanoparticle synthesis …
remain as a significant challenge. This work demonstrates chiral gold nanoparticle synthesis …
Antisense drug discovery and development technology considered in a pharmacological context
ST Crooke, X Liang, RM Crooke, BF Baker… - Biochemical …, 2021 - Elsevier
When coined, the term “antisense” included oligonucleotides of any structure, with any
chemical modification and designed to work through any post-RNA hybridization …
chemical modification and designed to work through any post-RNA hybridization …
Studies of DNA 'Breathing' by Polarization-Sweep Single-Molecule Fluorescence Microscopy of Exciton-Coupled (iCy3)2 Dimer-Labeled DNA Fork Constructs
J Maurer, CS Albrecht, P Herbert… - The Journal of …, 2023 - ACS Publications
Local fluctuations of the sugar–phosphate backbones and bases of DNA (often called DNA
'breathing') play a variety of critical roles in controlling the functional interactions of the DNA …
'breathing') play a variety of critical roles in controlling the functional interactions of the DNA …
Hierarchical assembly of single-stranded RNA
Single-stranded RNA (ssRNA) plays a major role in the flow of genetic information–most
notably, in the form of messenger RNA (mRNA)–and in the regulation of biological …
notably, in the form of messenger RNA (mRNA)–and in the regulation of biological …
Structure, stability and specificity of the binding of ssDNA and ssRNA with proteins
Recognition of single-stranded DNA (ssDNA) or single-stranded RNA (ssRNA) is important
for many fundamental cellular functions. A variety of single-stranded DNA-binding proteins …
for many fundamental cellular functions. A variety of single-stranded DNA-binding proteins …
Sequence-dependent three interaction site model for single-and double-stranded DNA
D Chakraborty, N Hori, D Thirumalai - Journal of chemical theory …, 2018 - ACS Publications
We develop a robust coarse-grained model for single-and double-stranded DNA by
representing each nucleotide by three interaction sites (TIS) located at the centers of mass of …
representing each nucleotide by three interaction sites (TIS) located at the centers of mass of …
Sensing the structural and conformational properties of single-stranded nucleic acids using electrometry and molecular simulations
Inferring the 3D structure and conformation of disordered biomolecules, eg, single stranded
nucleic acids (ssNAs), remains challenging due to their conformational heterogeneity in …
nucleic acids (ssNAs), remains challenging due to their conformational heterogeneity in …
Substrate sequence selectivity of APOBEC3A implicates intra-DNA interactions
Abstract The APOBEC3 (A3) family of human cytidine deaminases is renowned for providing
a first line of defense against many exogenous and endogenous retroviruses. However, the …
a first line of defense against many exogenous and endogenous retroviruses. However, the …