The lesions of Alzheimer disease include accumulation of proteins, losses of neurons and
synapses, and alterations related to reactive processes. Extracellular Aβ accumulation …

The aberrant accumulation of aggregated β-amyloid peptides (Aβ) as plaques is a hallmark
of Alzheimer's disease (AD) neuropathology and reduction of Aβ has become a leading …

Limbic-predominant age-related TDP-43 encephalopathy neuropathologic change (LATE-
NC) and Alzheimer's disease neuropathologic change (ADNC) are each associated with …

Neurodegenerative diseases are characterised by neuronal loss and cerebral deposition of
proteins with altered physicochemical properties. The major proteins are amyloid-β (Aβ), tau …

Objective: To assess the relationship between Alzheimer disease (AD)–related pathologic
changes in frontal cortical brain biopsy and AD biomarkers in ventricular vs lumbar CSF, and …

The retina is increasingly recognised as a potential source of biomarkers for
neurodegenerative diseases. Hallmark protein aggregates in the retinal neuronal tissue …

Since the description by Alois Alzheimer, more than 50 years have passed during which
senile dementia and pre-senile dementia have been considered Alzheimer disease (AD) on …

Sporadic Parkinson disease (sPD) or brainstem-predominant type of Lewy body (LB)
disease, and dementia with Lewy bodies (DLB), the two most frequent α-synucleinopathies …

Background Clinicopathological studies are important in determining the brain lesions
underlying dementia. Although almost 60% of individuals with dementia live in developing …

In vascular dementia (VaD) and Alzheimer's disease (AD), cerebral hypoperfusion and
blood‐brain barrier (BBB) leakiness contribute to brain damage. In this study, we have …