Pathogenesis and pathophysiology of pneumococcal meningitis

BB Mook-Kanamori, M Geldhoff… - Clinical microbiology …, 2011 - Am Soc Microbiol
Pneumococcal meningitis continues to be associated with high rates of mortality and long-
term neurological sequelae. The most common route of infection starts by nasopharyngeal …

Regulation of the cerebral circulation: role of endothelium and potassium channels

FM Faraci, DD Heistad - Physiological reviews, 1998 - journals.physiology.org
Faraci, Frank M., and Donald D. Heistad. Regulation of the Cerebral Circulation: Role of
Endothelium and Potassium Channels. Physiol. Rev. 78: 53–97, 1998.—Several new …

Infection-induced inflammation and cerebral injury in preterm infants

T Strunk, T Inder, X Wang, D Burgner… - The Lancet infectious …, 2014 - thelancet.com
Preterm birth and infectious diseases are the most common causes of neonatal and early
childhood deaths worldwide. The rates of preterm birth have increased over recent decades …

Community-acquired bacterial meningitis: risk stratification for adverse clinical outcome and effect of antibiotic timing

SI Aronin, P Peduzzi, VJ Quagliarello - Annals of internal medicine, 1998 - acpjournals.org
Background: Community-acquired bacterial meningitis causes substantial morbidity and
mortality in adults. Objective: To create and test a prognostic model for persons with …

Pathogenesis of bacterial meningitis: from bacteraemia to neuronal injury

KS Kim - Nature Reviews Neuroscience, 2003 - nature.com
Bacterial meningitis is an important cause of mortality and morbidity despite advances in
antimicrobial therapy. A key factor that contributes to the high prevalence of this condition is …

Bacterial endophthalmitis: epidemiology, therapeutics, and bacterium-host interactions

MC Callegan, M Engelbert, DW Parke… - Clinical microbiology …, 2002 - Am Soc Microbiol
Endophthalmitis is a severe inflammation of the interior of the eye caused by the introduction
of contaminating microorganisms following trauma, surgery, or hematogenous spread from a …

Pathogenesis and pathophysiology of pneumococcal meningitis

U Koedel, WM Scheld, HW Pfister - The Lancet infectious diseases, 2002 - thelancet.com
Until the introduction of antibiotics in the 1930s and 1940s, acute bacterial meningitis was
fatal in most cases. Since then it has become curable with a variable mortality and morbidity …

Pathophysiology of bacterial meningitis: mechanism (s) of neuronal injury

WM Scheld, U Koedel, B Nathan… - The Journal of …, 2002 - academic.oup.com
No bacterial disease has undergone a more dramatic change in epidemiology during the
past decade than acute bacterial meningitis. This review describes the changing …

Modif ication of ion homeostasis by lipid peroxidation: roles in neuronal degeneration and adaptive plasticity

MP Mattson - Trends in neurosciences, 1998 - cell.com
Oxyradicals attack double bonds of unsaturated fatty acids in cell membranes in a process
called membrane lipid peroxidation (MLP). This process occurs in many different acute and …

[HTML][HTML] Pneumococcal pneumolysin and H2O2 mediate brain cell apoptosis during meningitis

JS Braun, JE Sublett, D Freyer… - The Journal of …, 2002 - Am Soc Clin Investig
Pneumococcus is the most common and aggressive cause of bacterial meningitis and
induces a novel apoptosis-inducing factor–dependent (AIF–dependent) form of brain cell …