Thyroid cancer is rare, but it is the most frequent endocrine malignancy. Its prognosis is
generally favorable, especially in cases of well-differentiated thyroid cancers (DTCs), such …

Thyroid cancer typically has a good outcome following standard treatments, which include
surgery, radioactive iodine ablation and treatment with TSH-suppressive levothyroxine …

Collagen is the most important structural protein and also the main component of the extra-
cellular matrix (ECM). It plays a role in tumor progression. Collagen can be regulated by …

Dasatinib is one of the second-generation tyrosine kinase inhibitors used in imatinib
resistance and/or intolerance, as well as in the frontline setting in patients with chronic …

Objective: To compare healthcare resource utilization, costs, and treatment adherence
associated with dasatinib versus nilotinib treatment as second-line therapies in chronic …

Abstract All-trans-retinoic-acid (ATRA)-induced differentiation of human myeloid leukemia
cells is characterized by persistent mitogen-activated protein kinase (MAPK) signaling …

Chronic myeloid leukemia (CML) is characterized by the accumulation of Philadelphia
chromosome-positive (Ph+) myeloid cells. Ph+ cells occur via a reciprocal translocation …

Chronic myeloid leukemia (CML) is a myeloproliferative disorder caused by a single gene
mutation, a reciprocal translocation that originates the Bcr-Abl gene with constitutive tyrosine …

A founding premise of the human genome project was that knowledge of the spectrum of
abnormalities that comprise cancers and other human diseases would lead to improved …

Over the past two decades, tyrosine kinase inhibitors have become the foundation of chronic
myeloid leukemia (CML) treatment. The choice between imatinib and newer tyrosine kinase …