Proliferating cell nuclear antigen (PCNA) is an essential factor in DNA replication and repair.
It forms a homotrimeric ring that embraces the DNA and slides along it, anchoring DNA …

Successful genome duplication is required for cell proliferation and demands extraordinary
precision and accuracy. The mechanisms by which cells enter, progress through, and exit S …

The cullin-RING E3 ubiquitin ligase CRL4 Cdt2 has emerged as a master regulator of
genome stability, which targets key cell cycle proteins for proteolysis during S phase and …

Proliferating cell nuclear antigen (PCNA) is an excellent inhibition target to shut down highly
proliferative cells and thereby develop a broad‐spectrum cancer therapeutic. It interacts with …

Safeguards against excess DNA replication are often dysregulated in cancer, and driving
cancer cells towards over-replication is a promising therapeutic strategy. We determined …

Every time a cell copies its DNA the genetic material is exposed to the acquisition of
mutations and genomic alterations that corrupt the information passed on to daughter cells …

The human sliding clamp, Proliferating Cell Nuclear Antigen (hPCNA), interacts with over
200 proteins through a conserved binding motif, the PIP-box, to orchestrate DNA replication …

In eukaryotic cells, DNA replication licensing is precisely regulated to ensure that the
initiation of genomic DNA replication in S phase occurs once and only once for each mitotic …

The spindle assembly checkpoint (SAC) prevents premature chromosome segregation by
inactivating the anaphase promoting complex/cyclosome (APC/C) until all chromosomes are …

The maintenance of genome integrity is essential for cellular survival and propagation. It
relies upon the accurate and timely replication of the genetic material, as well as the rapid …