DNA methylation, an epigenetic modification, regulates gene transcription and maintains
genome stability. DNA methyltransferase (DNMT) inhibitors can activate silenced genes at …

Breast cancer is a life-threatening disease known for its extensive molecular heterogeneity.
The study of the breast cancer epigenome has revealed potential avenues for improving …

Introduction Despite its desirable half-life and low energy Auger electrons that travel further
than for other radionuclides, 67 Ga has been neglected as a therapeutic radionuclide. Here …

Background Poor-responsiveness of tumors to radiotherapy is a major clinical problem.
Owing to the dynamic nature of the epigenome, the identification and targeting of potential …

Preoperative radiotherapy or chemoradiotherapy has become a standard procedure for
treatment of patients with locally advanced colorectal cancer (CRC). However, patients' …

This review describes artificial modular nanotransporters (MNTs) delivering their cargos into
target cells and then into the nuclei–the most vulnerable cell compartment for most …

Introduction Thallium-201 is a radionuclide that has previously been used clinically for
myocardial perfusion scintigraphy. Although in this role it has now been largely replaced by …

High resistance to traditional chemo-and radiotherapies contributes to the poor prognosis of
pancreatic cancer (PC). Methyl-CpG binding domain protein 1 (MBD1), which plays an …

Matrix metalloproteinases (MMPs) and specific endogenous tissue inhibitors of
metalloproteinases (TIMPs) mediate rupture of the fetal membranes in both physiological …

In oncology, the holy grail of radiotherapy is specific radiation dose deposition in tumours
with minimal healthy tissue toxicity. If used appropriately, injectable, systemic radionuclide …