Brain development is an extraordinarily complex process achieved through the spatially and
temporally regulated release of key patterning factors. In vitro neurodevelopmental models …

The potential to generate virtually any differentiated cell type from embryonic stem cells
(ESCs) offers the possibility to establish new models of mammalian development and to …

Pluripotent cells emerge as a naive founder population in the blastocyst, acquire capacity for
germline and soma formation, and then undergo lineage priming. Mouse embryonic stem …

The mouse inner cell mass (ICM) segregates into the epiblast and primitive endoderm (PrE)
lineages coincident with implantation of the embryo. The epiblast subsequently undergoes …

Efficient differentiation of embryonic stem cells (ESCs) and induced pluripotent stem cells
(iPSCs) to a variety of lineages requires step-wise approaches replicating the key …

The potential of human embryonic stem (hES) cells to differentiate into cell types of a variety
of organs has generated much excitement over the possible use of hES cells in therapeutic …

Although the first mouse embryonic stem (ES) cell lines were derived 25 years ago, using
feeder-layer-based blastocyst cultures, subsequent efforts to extend the approach to other …

The functional heart is comprised of distinct mesoderm-derived lineages including
cardiomyocytes, endothelial cells and vascular smooth muscle cells. Studies in the mouse …

Bone morphogenetic protein-4 (BMP-4) is a member of the TGF-beta superfamily of
polypeptide signaling molecules, closely related to BMP-2 and to Drosophila …

The efficient generation of hematopoietic stem cells from human pluripotent stem cells is
dependent on the appropriate specification of the definitive hematopoietic program during …