Lung cancer staging and prognosis

GA Woodard, KD Jones, DM Jablons - Lung cancer: treatment and …, 2016 - Springer
The seventh edition of the non-small cell lung cancer (NSCLC) TNM staging system was
developed by the International Association for the Staging of Lung Cancer (IASLC) Lung …

[HTML][HTML] Recurrence after surgery in patients with NSCLC

H Uramoto, F Tanaka - Translational lung cancer research, 2014 - ncbi.nlm.nih.gov
Surgery remains the only potentially curative modality for early-stage non-small cell lung
cancer (NSCLC) patients and tissue availability is made possible. However, a proportion of …

Development and validation of an individualized immune prognostic signature in early-stage nonsquamous non–small cell lung cancer

B Li, Y Cui, M Diehn, R Li - JAMA oncology, 2017 - jamanetwork.com
Importance The prevalence of early-stage non–small cell lung cancer (NSCLC) is expected
to increase with recent implementation of annual screening programs. Reliable prognostic …

Addressing overdiagnosis and overtreatment in cancer: a prescription for change

LJ Esserman, IM Thompson, B Reid, P Nelson… - The lancet …, 2014 - thelancet.com
A vast range of disorders—from indolent to fast-growing lesions—are labelled as cancer.
Therefore, we believe that several changes should be made to the approach to cancer …

Updated prognostic factors in localized NSCLC

S Garinet, P Wang, A Mansuet-Lupo, L Fournel… - Cancers, 2022 - mdpi.com
Simple Summary In resected lung cancer, adjuvant and neoadjuvant chemotherapy
following surgery are currently mainly based on TNM classification. With the validation and …

Quantitative computed tomographic descriptors associate tumor shape complexity and intratumor heterogeneity with prognosis in lung adenocarcinoma

O Grove, AE Berglund, MB Schabath, HJWL Aerts… - PloS one, 2015 - journals.plos.org
Two CT features were developed to quantitatively describe lung adenocarcinomas by
scoring tumor shape complexity (feature 1: convexity) and intratumor density variation …

Predictive gene signature in MAGE-A3 antigen-specific cancer immunotherapy

F Ulloa-Montoya, J Louahed, B Dizier… - Journal of Clinical …, 2013 - ascopubs.org
Purpose To detect a pretreatment gene expression signature (GS) predictive of response to
MAGE-A3 immunotherapeutic in patients with metastatic melanoma and to investigate its …

[HTML][HTML] Validation of a histology-independent prognostic gene signature for early-stage, non–small-cell lung cancer including stage IA patients

SD Der, J Sykes, M Pintilie, CQ Zhu, D Strumpf… - Journal of thoracic …, 2014 - Elsevier
Background: Patients with early-stage non–small-cell lung carcinoma (NSCLC) may benefit
from treatments based on more accurate prognosis. A 15-gene prognostic classifier for …

Biomarker discovery in non–small cell lung cancer: integrating gene expression profiling, meta-analysis, and tissue microarray validation

J Botling, K Edlund, M Lohr, B Hellwig, L Holmberg… - Clinical cancer …, 2013 - AACR
Purpose: Global gene expression profiling has been widely used in lung cancer research to
identify clinically relevant molecular subtypes as well as to predict prognosis and therapy …

Big data in basic and translational cancer research

P Jiang, S Sinha, K Aldape, S Hannenhalli… - Nature Reviews …, 2022 - nature.com
Historically, the primary focus of cancer research has been molecular and clinical studies of
a few essential pathways and genes. Recent years have seen the rapid accumulation of …