Rheumatic diseases are a collection of disorders defined by the presence of inflammation
and destruction of joints and internal organs. A common feature of these diseases is the …

Rheumatoid arthritis (RA) is considered to be an inflammatory disorder whereas OA is not
an overtly inflammatory disorder as RA but certain inflammatory cytokines and periodic …

There is considerable evidence that osteoclasts are involved in the pathogenesis of focal
bone erosion in rheumatoid arthritis. Tumor necrosis factor-related activation-induced …

K/BxN T cell receptor transgenic mice are a model of inflammatory arthritis, similar to
rheumatoid arthritis. Disease in these animals is focused specifically on the joints but stems …

The complement system is a major component of the immune system and plays a central
role in many protective immune processes, including circulating immune complex …

The K/BxN serum-transfer arthritis (STA) model is a murine model in which the
immunological mechanisms occurring in rheumatoid arthritis (RA) and other arthritides can …

In spontaneous inflammatory arthritis of K/BxN T cell receptor transgenic mice, the effector
phase of the disease is provoked by binding of immunoglobulins (Igs) to joint surfaces …

Background Rheumatoid arthritis (RA) is a chronic autoimmune disorder affecting∼ 1% of
the population. The disease results from the interplay between an individual's genetic …

Arthritis in the K/BxN mouse model results from pathogenic immunoglobulins (Igs) that
recognize the ubiquitous cytoplasmic enzyme glucose-6-phosphate isomerase (GPI). But …

Introduction There is increasing evidence that autoantibodies and immune complexes (ICs)
contribute to synovitis in rheumatoid arthritis (RA), yet the autoantigens incorporated in ICs …