A markedly reduced interest or pleasure in activities previously considered pleasurable is a
main symptom in mood disorder and psychosis and is often present in other psychiatric …

Animal models of psychiatric disorders are usually discussed with regard to three criteria first
elaborated by Willner; face, predictive and construct validity. Here, we draw the history of …

Zebrafish are increasingly being used in behavioral neuroscience,
neuropsychopharmacology and neurotoxicology. Recently, behavioral screens used to …

The valproic acid (VPA) animal model of autism spectrum disorder (ASD) is one of the most
widely used animal model in the field. Like any other disease models, it can't model the …

Judgment bias tasks (JBTs) are considered as a family of promising tools in the assessment
of emotional states of animals. JBTs provide a cognitive measure of optimism and/or …

The scientific community is increasingly concerned with the proportion of published
“discoveries” that are not replicated in subsequent studies. The field of rodent behavioral …

It is widely believed that environmental standardization is the best way to guarantee
reproducible results in animal experiments. However, mounting evidence indicates that …

Human epidemiological studies have provided compelling evidence that the risk of
developing schizophrenia is significantly enhanced following prenatal and/or perinatal …

Rodent marble-burying behavior in the marble-burying test (MBT) is employed as a model or
measure to study anxiety-and compulsive-like behaviors or anxiolytic and anticompulsive …

The neurodevelopmental hypothesis of schizophrenia has been highly influential in shaping
our current thinking about modeling the disease in animals. Based on the findings provided …