Thirty years after the discovery of its production by activated macrophages, our appreciation
of the diverse roles of nitric oxide (NO) continues to grow. Recent findings have not only …

Studies of the biofilm life cycle can identify novel targets and strategies for improving biofilm
control measures. Of particular interest are dispersal events, where a subpopulation of cells …

Innate immune responses play a critical role in controlling acute infections due to
Pseudomonas aeruginosa in both mice and in humans. In this review we focus on innate …

Current approaches to treating inflammatory bowel disease focus on the suppression of
overactive immune responses, the removal of reactive intestinal oxygen species, and …

DNA methylation is an epigenetic modification that is highly disrupted in response to
cigarette smoke and involved in a wide spectrum of malignant and nonmalignant diseases …

Recent studies have indicated that the inflammasome plays a critical role in the
pathogenesis of vascular diseases. However, the pathological relevance of this …

Although Nlrp3 inflammasome activation in macrophages has been shown to be critical for
the development of atherosclerosis upon atherogenic stimuli, it remains unknown whether …

Aims: This study hypothesized that activation of endothelial nucleotide oligomerization
domain-like receptor protein with pyrin domain containing 3 (Nlrp3) inflammasomes directly …

IL-8 released from bronchial epithelial cells infected with Pseudomonas aeruginosa plays a
crucial role in the chronic lung pathology of patients affected by cystic fibrosis. Novel anti …

Cells coordinate and integrate various functional modules that control their dynamics,
intracellular trafficking, metabolism and gene expression. Such capacity is mediated by …