An in vitro model of human ovarian follicles would greatly benefit the study of female
reproduction. Ovarian development requires the combination of germ cells and several …

Mammalian female reproduction requires a functional ovary. Competence of the ovary is
determined by the quality of its basic unit–ovarian follicles. A normal follicle consists of an …

Gonadal development is the first step in human reproduction. Aberrant gonadal
development during the fetal period is a major cause of disorders/differences of sex …

The testis is responsible for sperm production and androgen synthesis. Abnormalities in
testis development and function lead to disorders of sex development and male infertility …

Abstract Context Steroidogenic factor 1 (NR5A1/SF-1) is a nuclear receptor that regulates
sex development, steroidogenesis, and reproduction. Genetic variants in NR5A1/SF-1 are …

The heterogeneity of CARM1 controls first cell fate bias during early mouse development.
However, how this heterogeneity is established is unknown. Here, we show that Carm1 …

The Y-linked SRY gene initiates mammalian testis-determination. However, how the
expression of SRY is regulated remains elusive. Here, we demonstrate that a conserved …

Despite significant advancements in rare genetic disease diagnostics, many patients with
rare genetic disease remain without a molecular diagnosis. Novel tools and methods are …

NR5A1/SF-1 (Steroidogenic factor-1) variants may cause mild to severe differences of sex
development (DSD) or may be found in healthy carriers. The NR5A1/SF-1 c. 437G> C/p …

In the space of 50 years, we have seen incredible achievements in human reproductive
medicine. With these leaps forward, it is no wonder that there is a major interest in women's …