Protein kinase D (PKD) is an evolutionarily conserved protein kinase family with structural,
enzymological, and regulatory properties different from the PKC family members. Signaling …

The formation of axons and dendrites and maintenance of the neuron's vastly expanded
surface require the continuous addition of new membrane. This is achieved by membrane …

Protein kinase D (PKD) mediates the actions of stimuli that promote diacylglycerol (DAG)
biogenesis. By phosphorylating effectors that regulate transcription, fission and polarized …

The Reelin ligand regulates a Dab1-dependent signaling pathway required for brain
lamination and normal dendritogenesis, but the specific mechanisms underlying these …

This comprehensive review article dives deep into the Golgi apparatus, an essential
organelle in cellular biology. Beginning with its discovery during the 19th century until …

The highly specialized morphology of a neuron, typically consisting of a long axon and
multiple branching dendrites, lies at the core of the principle of dynamic polarization …

The neuronal Golgi apparatus (GA) localizes to the perinuclear region and dendrites as
tubulo-vesicular structures designated Golgi outposts (GOPs). Current evidence suggests …

Diacylglycerol signals by binding and activating C1 domain-containing proteins expressed
principally in neuronal and immune tissues. This restricted expression profile suggests that …

Axonal elongation is one of the hallmarks of neuronal polarization. This phenomenon
requires axonal membrane growth by exocytosis of plasmalemmal precursor vesicles …

Abstract Protein kinase D1 (PKD1) is a serine-threonine kinase that regulates various
functions within the cell, including cell proliferation, apoptosis, adhesion, and cell motility. In …