Drug repurposing for cancer therapy

Y Xia, M Sun, H Huang, WL Jin - Signal Transduction and Targeted …, 2024 - nature.com
Cancer, a complex and multifactorial disease, presents a significant challenge to global
health. Despite significant advances in surgical, radiotherapeutic and immunological …

Research progress in the molecular mechanism of ferroptosis in Parkinson's disease and regulation by natural plant products

K Yang, L Zeng, J Zeng, Y Deng, S Wang, H Xu… - Ageing Research …, 2023 - Elsevier
Parkinson's disease (PD) is the second most prevalent neurodegenerative disorder of the
central nervous system after Alzheimer's disease. The current understanding of PD focuses …

Anticancer mechanism of flavonoids on high-grade adult-type diffuse gliomas

SC Wong, MNA Kamarudin, R Naidu - Nutrients, 2023 - mdpi.com
High-grade adult-type diffuse gliomas are the most common and deadliest malignant adult
tumors of the central nervous system. Despite the advancements in the multimodality …

A comprehensive review of apigenin a dietary flavonoid: biological sources, nutraceutical prospects, chemistry and pharmacological insights and health benefits

A Singh, J Singh, G Parween, R Khator… - Critical Reviews in …, 2024 - Taylor & Francis
A multitude of plant-derived bioactive compounds have shown significant promise in
preventing chronic illnesses, with flavonoids constituting a substantial class of naturally …

Recent advancement in bioeffect, metabolism, stability, and delivery systems of apigenin, a natural flavonoid compound: challenges and perspectives

P Chen, F Chen, ZL Guo, J Lei, B Zhou - Frontiers in Nutrition, 2023 - frontiersin.org
Apigenin is a bioflavonoid compound that is widely present in dietary plant foods and
possesses biological activities that protect against immune, cardiovascular, and …

Synergism antiproliferative effects of apigenin and naringenin in NSCLC cells

X Liu, T Zhao, Z Shi, C Hu, Q Li, C Sun - Molecules, 2023 - mdpi.com
Non-small cell lung cancer (NSCLC) is one of the leading cancer killers. Apigenin (Api) and
Naringenin (Nar) are natural bioactive substances obtained in various vegetables and fruits …

Unveiling the therapeutic promise of natural products in alleviating drug‐induced liver injury: Present advancements and future prospects

D Singh, MA Khan, HR Siddique - Phytotherapy Research, 2024 - Wiley Online Library
Drug‐induced liver injury (DILI) refers to adverse reactions to small chemical compounds,
biological agents, and medical products. These reactions can manifest as acute or chronic …

Apigenin-7-glucoside-loaded nanoparticle alleviates intestinal ischemia-reperfusion by ATF3/SLC7A11-mediated ferroptosis

X Zhao, Z Wang, G Wu, L Yin, L Xu, N Wang… - Journal of Controlled …, 2024 - Elsevier
Intestinal ischemia reperfusion injury (II/R injury) is a common and intractable
pathophysiological process in critical patients, for which exploring new treatments and …

Protective effects of alpha-lipoic acid, resveratrol, and apigenin against oxidative damages, histopathological changes, and mortality induced by lung irradiation in rats

N Seyedpour, E Motevaseli, S Taeb… - Current …, 2024 - ingentaconnect.com
Aim: This study investigated the protective effects of three antioxidants on radiationinduced
lung injury. Background: Oxidative stress is one of the key outcomes of radiotherapy in …

[HTML][HTML] Dietary Polyphenols and Gut Microbiota Cross-Talk: Molecular and Therapeutic Perspectives for Cardiometabolic Disease: A Narrative Review

R Cano, V Bermúdez, N Galban, B Garrido… - International Journal of …, 2024 - mdpi.com
The intricate interplay between the gut microbiota and polyphenols has emerged as a
captivating frontier in understanding and potentially harnessing the therapeutic potential of …