Brain Chimeroids reveal individual susceptibility to neurotoxic triggers
N Antón-Bolaños, I Faravelli, T Faits, S Andreadis… - Nature, 2024 - nature.com
Interindividual genetic variation affects the susceptibility to and progression of many
diseases,. However, efforts to study how individual human brains differ in normal …
diseases,. However, efforts to study how individual human brains differ in normal …
Axon Initial Segment Structure and Function in Health and Disease
PM Jenkins, KJ Bender - Physiological Reviews, 2024 - journals.physiology.org
At the simplest level, neurons are structured to integrate synaptic input and perform
computational transforms on that input, converting it into an action potential (AP) code. This …
computational transforms on that input, converting it into an action potential (AP) code. This …
The evolution of patch-clamp electrophysiology: robotic, multiplex, and dynamic
MR Ghovanloo, SD Dib-Hajj, SG Waxman - Molecular Pharmacology, 2024 - Elsevier
The patch-clamp technique has been the gold standard for analysis of excitable cells. Since
its development in the 1980s it has contributed immensely to our understanding of neurons …
its development in the 1980s it has contributed immensely to our understanding of neurons …
The contribution of NaV1.6 to the efficacy of voltage‐gated sodium channel inhibitors in wild type and NaV1.6 gain‐of‐function (GOF) mouse seizure control
JP Johnson Jr, T Focken, P Karimi Tari… - British Journal of …, 2024 - Wiley Online Library
Background and Purpose Inhibitors of voltage‐gated sodium channels (NaVs) are important
anti‐epileptic drugs, but the contribution of specific channel isoforms is unknown since …
anti‐epileptic drugs, but the contribution of specific channel isoforms is unknown since …
Small-molecule natural product sophoricoside reduces peripheral neuropathic pain via directly blocking of NaV1. 6 in dorsal root ganglion nociceptive neurons
W Guo, H Yang, Y Wang, T Liu, Y Pan… - …, 2024 - nature.com
Peripheral neuropathic pain poses a significant global health challenge. Current drugs for
peripheral neuropathic pain often fall short in efficacy or come with severe side effects …
peripheral neuropathic pain often fall short in efficacy or come with severe side effects …
NaV1.6 inhibition drives the efficacy of voltage-gated sodium channel inhibitors to prevent electrically induced seizures in both wild type and Scn8aN1768D/+ gain …
JP Johnson, T Focken, PK Tari, C Dube, SJ Goodchild… - BioRxIV, 2023 - biorxiv.org
Inhibitors of voltage-gated sodium channels (NaVs) are important anti-epileptic drugs, but
the contribution of specific channel isoforms is unknown since available inhibitors are …
the contribution of specific channel isoforms is unknown since available inhibitors are …
A patient organization perspective: charting the course to a cure for SCN2A-related disorders
LF Schust, J Burke, C SanInocencio… - … Advances in Rare …, 2024 - journals.sagepub.com
The SCN2A gene encodes the Nav1. 2 protein, a voltage-gated sodium channel crucial for
initiating and transmitting action potentials in neurons. Dysfunction in Nav1. 2, often …
initiating and transmitting action potentials in neurons. Dysfunction in Nav1. 2, often …
Differential roles of NaV1.2 and NaV1.6 in neocortical pyramidal cell excitability
JD Garcia, C Wang, E Banks, T Fenton, JM DeKeyser… - bioRxiv, 2024 - biorxiv.org
Mature neocortical pyramidal cells functionally express two sodium channel (NaV) isoforms:
NaV1. 2 and NaV1. 6. These isoforms are differentially localized to pyramidal cell …
NaV1. 2 and NaV1. 6. These isoforms are differentially localized to pyramidal cell …