Background Phenotypic heterogeneity is a major impediment to the elucidation of the
neurobiology and genetics of bipolar disorder. Endophenotype could help in reducing …

Background Neurocognitive deficits are present in bipolar disorder (BD) patients and their
unaffected (nonbipolar) relatives, but it is not clear which domains are most often impaired …

Background Bipolar disorder (BD) is characterized by a dysregulation of affect and impaired
integration of emotion with cognition. These traits are also expressed in probands at high …

Background Youth with a family history of bipolar disorder (BD) may be at increased risk for
mood disorders and for developing side effects after antidepressant exposure. The …

Emerging evidence suggests that psychiatric disorders are associated with disturbances in
structural brain networks. Little is known, however, about brain networks in those at high risk …

This study aimed to identify neuroimaging measures associated with risk for, or protection
against, bipolar disorder by comparing youth offspring of parents with bipolar disorder …

Bipolar disorder (BD) is characterized by emotional dysregulation and cognitive deficits
associated with abnormal connectivity between subcortical—primarily emotional processing …

The emotional and cognitive vulnerabilities that precede the development of bipolar disorder
are poorly understood. The inferior frontal gyrus—a key cortical hub for the integration of …

Objective: To compare neurofunctional responses in emotional and attentional networks of
psychostimulant-free ADHD youth with and without familial risk for bipolar I disorder (BD) …

BackgroundFronto-limbic structural brain abnormalities have been reported in patients with
bipolar disorder (BD), but findings in individuals at increased genetic risk of developing BD …