Toad venom, a traditional natural medicine, has been used for hundreds of years in China
for treating different diseases. Many studies have been performed to elucidate the …

Bufadienolides, naturally found in toad venoms having steroid‐like structures, reveal
antiproliferative effects at low doses. However, their application as anticancer drugs is …

Hepatocellular carcinoma (HCC) is a deadly form of cancer without effective chemotherapy
so far. Currently, only sorafenib, a multitargeted tyrosine kinase inhibitor, slightly improves …

In drug discovery, reliable and fast dereplication of known compounds is essential for
identification of novel bioactive compounds. Here, we show an integrated approach using …

Clinical data show that the incidence and mortality rates of cancer are rising continuously,
and cancer has become an ongoing public health challenge worldwide. Excitingly, the …

Abstract Ethnopharmacological relevance Bufo gargarizans (Cantor, 1842)(BGC), a
traditional medicinal animal distributed in many provinces of China, is well known for the …

Despite the increasing use of protoplasts in plant biotechnology research, shoot
regeneration from protoplasts remains challenging. In this study, we investigated the factors …

Toad venom contains a large number of bufadienolides, which have a variety of
pharmacological activities, including antitumor, cardiovascular, anti-inflammatory, analgesic …

Little is known on the composition of Peruvian Amazon toad venoms. The large toad
Rhinella marina is common in the cleared tropical forests of the Iquitos region and is …

Shexiang Tongxin dropping pill (STP) is a traditional Chinese medicine formula that consists
of total saponins of ginseng, synthetic Calculus bovis, bear gall, Venenum bufonis, borneol …