Satellite glial cells (SGCs) closely envelop cell bodies of neurons in sensory, sympathetic
and parasympathetic ganglia. This unique organization is not found elsewhere in the …

Chronic pain affects one in five of the general population and is the third most important
cause of disability-adjusted life-years globally. Unfortunately, treatment remains inadequate …

Peripheral sensory neurons regenerate their axon after nerve injury to enable functional
recovery. Intrinsic mechanisms operating in sensory neurons are known to regulate nerve …

Current information indicates that glial cells participate in all the normal and pathological
processes of the central nervous system. Although much less is known about satellite glial …

Background In the not-too-distant past, the dorsal root ganglion (DRG) was portrayed as a
passive neural structure without involvement in the development or maintenance of chronic …

Background The dorsal root ganglion (DRG), in the not too distant past, had been thought of
as a passive organ not involved in the development of abnormal aberrent neuropathic pain …

Studies of the structural organization and functions of the cell body of a neuron (soma) and
its surrounding satellite glial cells (SGCs) in sensory ganglia have led to the realization that …

Preclinical studies have identified glial cells as pivotal players in the genesis and
maintenance of neuropathic pain after nerve injury associated with diabetes, chemotherapy …

Background Chemotherapy‐induced peripheral neuropathy is a serious side effect in cancer
treatment, a major manifestation being neuropathic pain that can be debilitating and can …

Astroglia are neural cells, heterogeneous in form and function, which act as supportive
elements of the central nervous system; astrocytes contribute to all aspects of neural …