Colorectal cancer (CRC) is the third cause of cancer death worldwide. Although, in some
cases, treatment can increase patient survival and reduce cancer recurrence, in many …

Aim Approximately 20% of patients treated with neoadjuvant chemoradiotherapy (nCRT) for
locally advanced rectal cancer achieve a pathological complete response (p CR) while the …

Background Accurate prediction of tumour response to neoadjuvant chemoradiotherapy
enables personalised perioperative therapy for locally advanced rectal cancer. We aimed to …

Objective: This study evaluates factors associated with a pathologic complete response
(pCR) after neoadjuvant chemoradiation for rectal cancer. Summary Background Data …

Purpose European Organisation for Research and Treatment of Cancer (EORTC) trial
22921 compared adjuvant fluorouracil-based chemotherapy (CT) to no adjuvant treatment in …

BACKGROUND The objective of this study was to identify predictive factors for pathologic
complete response and tumor downstaging after preoperative chemoradiation for rectal …

A systems approach is being applied in many areas of the biological sciences, particularly in
cancer research. The coordinated, simultaneous extraction of DNA, RNA, and proteins from …

Activation of Wnt/β-catenin signaling plays a central role in the development and
progression of colorectal cancer. The Wnt-transcription factor, TCF7L2, is overexpressed in …

Prognostication of newly diagnosed colorectal cancer (CRC) predominantly relies on stage
as defined by the UICC-TNM and American Joint Committee on Cancer classifications …

Background Gene expression profiling is a highly sensitive technique which is used for
profiling tumor samples for medical prognosis. RNA quality and degradation influence the …