Increasing evidence suggests that ion channels and pumps not only regulate membrane
potential, ion homeostasis, and electric signaling in excitable cells but also play important …

Cell motility is central to tissue homeostasis in health and disease, and there is hardly any
cell in the body that is not motile at a given point in its life cycle. Important physiological …

Voltage-gated Na+ channels (VGSCs) in mammals contain a pore-forming α subunit and
one or more β subunits. There are five mammalian β subunits in total: β1, β1B, β2, β3, and …

Channelopathies are disorders caused by abnormal ion channel function in differentiated
excitable tissues. We discovered a unique neurodevelopmental channelopathy resulting …

Voltage-gated sodium channels (VGSCs) are responsible for the initiation and propagation
of action potentials in excitable cells. VGSCs in mammalian brain are heterotrimeric …

Targeted therapy is considerably changing the treatment and prognosis of cancer.
Progressive understanding of the molecular mechanisms that regulate the establishment …

Dravet syndrome (also called severe myoclonic epilepsy of infancy) is one of the most
severe forms of childhood epilepsy. Most patients have heterozygous mutations in SCN1A …

Voltage-gated Na+ channels (VGSCs) are macromolecular protein complexes containing a
pore-forming α subunit and smaller non-pore-forming β subunits. VGSCs are expressed in …

Abstract Voltage-gated Na+ channels (VGSCs) are heteromeric membrane protein
complexes containing pore-forming α subunits and smaller, non-pore-forming β subunits …

Voltage-gated Na+ channel (VGSC) β Subunits are not “auxiliary.” These multi-functional
molecules not only modulate Na+ current (INa), but also function as cell adhesion molecules …