Genomic instability is the hallmark of various cancers with the increasing accumulation of
DNA damage. The application of radiotherapy and chemotherapy in cancer treatment is …

Many clustered regularly interspaced short palindromic repeats (CRISPR)-CRISPR-
associated protein 9 (Cas9)-based genome editing technologies take advantage of Cas …

Homologous recombination enables the cell to access and copy intact DNA sequence
information in trans, particularly to repair DNA damage affecting both strands of the double …

The multistep process of cancer progresses over many years. The prevention of mutations
by DNA repair pathways led to an early appreciation of a role for repair in cancer avoidance …

Homologous recombination (HR) is a major pathway for the repair of DNA double-strand
breaks in mammalian cells, the defining step of which is homologous strand exchange …

Genetic abnormalities in the DNA repair genes BRCA1 and BRCA2 predispose to hereditary
breast and ovarian cancer (HBOC). However, only approximately 25% of cases of HBOC …

Mutations in the BRCA2 gene are associated with sporadic and familial cancer, cause
genomic instability and sensitize cancer cells to inhibition by the poly (ADP-ribose) …

Homologous recombination (HR) is required for accurate chromosome segregation during
the first meiotic division and constitutes a key repair and tolerance pathway for complex DNA …

Human cancers are characterized by the presence of oncogene-induced DNA replication
stress (DRS), making them dependent on repair pathways such as break-induced …

Microarrays can measure the expression of thousands of genes to identify changes in
expression between different biological states. Methods are needed to determine the …