Pediatric brain tumors comprise a diverse set of diseases.(Epi) genomic analyses have
provided insights into the biology of these tumors, stratifying them into distinct subtypes with …

Mitochondria are pivotal contributors to cancer mechanisms due to their homeostatic and
pathological roles in cellular bioenergetics, biosynthesis, metabolism, signaling, and …

Abstract H3K27M-mutant diffuse midline gliomas (DMGs) express high levels of the
disialoganglioside GD2 (ref.). Chimeric antigen receptor-modified T cells targeting GD2 …

The majority of cancer cells have a functional mitochondrial electron transport chain (ETC).
Mitochondrial complex I is the primary entry point into the ETC, where oxidative …

PURPOSE Histone 3 (H3) K27M–mutant diffuse midline glioma (DMG) has a dismal
prognosis with no established effective therapy beyond radiation. This integrated analysis …

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Recent clinical trials for H3K27-altered diffuse midline gliomas (DMGs) have shown much
promise. We present a consensus roadmap and identify three major barriers:(1) refinement …

Based on the founding member of imipridones, ONC201, a class of dehydrogenated
imipridone derivatives was designed, synthesized, and evaluated in a series of biochemical …

Hepatocellular carcinoma (HCC) is the most common form of liver cancer, accounting for
approximately 90% of all cases. ONC201, a member of the imipridone drug family, has …

Glioblastoma (GBM) is defined by heterogeneous and resilient cell populations that closely
reflect neurodevelopmental cell types. Although it is clear that GBM echoes early and …