Mitochondrial ADP/ATP carriers transport ADP into the mitochondrial matrix for ATP
synthesis, and ATP out to fuel the cell, by cycling between cytoplasmic-open and matrix …

Gene silencing is essential for regulating cell fate in eukaryotes. Altered chromatin
architectures contribute to maintaining the silenced state in a variety of species. The silent …

Arenaviridae synthesize viral mRNAs using short capped primers presumably acquired from
cellular transcripts by a 'cap-snatching'mechanism. Here, we report the crystal structure and …

Voltage-gated sodium channels are targets for a range of pharmaceutical drugs developed
for the treatment of neurological diseases. Cannabidiol (CBD), the non-psychoactive …

A sulfide: quinone oxidoreductase (SQR) was isolated from the membranes of the
hyperthermoacidophilic archaeon Acidianus ambivalens, and its X-ray structure, the first …

Protein N-glycosylation is a widespread post-translational modification. The first committed
step in this process is catalysed by dolichyl-phosphate N-acetylglucosamine …

Methicillin-resistant Staphylococcus aureus (MRSA) is an antibiotic-resistant strain of S.
aureus afflicting hospitals and communities worldwide. Of greatest concern is its …

tRNAs are typically transcribed with extended 5′ and 3′ ends that must be removed
before they attain their active form. One of the first steps of tRNA processing in nearly every …

The morphogenesis of poxviruses such as vaccinia virus (VACV) sees the virion shape
mature from spherical to brick-shaped. Trimeric capsomers of the VACV D13 protein form a …

Herpesviruses acquire their membrane envelopes in the cytoplasm of infected cells via a
molecular mechanism that remains unclear. Herpes simplex virus (HSV)− 1 proteins pUL7 …