Polyploidy (or whole-genome duplication) is the condition of having more than two basic
sets of chromosomes. Polyploidization is well tolerated in many species and can lead to …

With 296 million cases estimated worldwide, chronic hepatitis B virus (HBV) infection is the
most common risk factor for hepatocellular carcinoma (HCC). HBV-encoded oncogene X …

MYH9 has dual functions in tumors. However, its role in inducing tumor stemness in
hepatocellular carcinoma (HCC) is not yet determined. Here, we found that MYH9 is an …

Background Many molecular alterations are shared by embryonic liver development and
hepatocellular carcinoma (HCC). Identifying the common molecular events would provide a …

Tumors are renowned as intricate systems that harbor heterogeneous cancer cells with
distinctly diverse molecular signatures, sizes and genomic contents. Among those various …

Background & Aims HBV causes hepatocellular carcinoma (HCC). While it was recently
shown that the ability of HBV X protein (HBx) to impair the Smc5/6 (structural maintenance of …

A balanced increase in DNA content (ploidy) is observed in some human cell types,
including bone-resorbing osteoclasts, platelet-producing megakaryocytes, cardiomyocytes …

Hepatocyte organoids (HOs) generated in vitro are powerful tools for liver regeneration.
However, previously reported HOs have mostly been fetal in nature with low expression …

Polyploidy, a condition in which more than two sets of chromosomes are present in a cell, is
a characteristic feature of hepatocytes. A significant number of hepatocytes physiologically …

The process of metabolic liver zonation is spontaneously established by assigning
distributed tasks to hepatocytes along the porto-central blood flow. Hepatocytes fulfil critical …