Nanomedicine for brain cancer
CNS tumors remain among the deadliest forms of cancer, resisting conventional and new
treatment approaches, with mortality rates staying practically unchanged over the past 30 …
treatment approaches, with mortality rates staying practically unchanged over the past 30 …
CNS drug design: balancing physicochemical properties for optimal brain exposure
Z Rankovic - Journal of medicinal chemistry, 2015 - ACS Publications
The human brain is a uniquely complex organ, which has evolved a sophisticated protection
system to prevent injury from external insults and toxins. Designing molecules that can …
system to prevent injury from external insults and toxins. Designing molecules that can …
A stable and reproducible human blood-brain barrier model derived from hematopoietic stem cells
The human blood brain barrier (BBB) is a selective barrier formed by human brain
endothelial cells (hBECs), which is important to ensure adequate neuronal function and …
endothelial cells (hBECs), which is important to ensure adequate neuronal function and …
Unbound Brain-to-Plasma Partition Coefficient, Kp,uu,brain—a Game Changing Parameter for CNS Drug Discovery and Development
Purpose More than 15 years have passed since the first description of the unbound brain-to-
plasma partition coefficient (Kp, uu, brain) by Prof. Margareta Hammarlund-Udenaes, which …
plasma partition coefficient (Kp, uu, brain) by Prof. Margareta Hammarlund-Udenaes, which …
On the rate and extent of drug delivery to the brain
To define and differentiate relevant aspects of blood–brain barrier transport and distribution
in order to aid research methodology in brain drug delivery. Pharmacokinetic parameters …
in order to aid research methodology in brain drug delivery. Pharmacokinetic parameters …
Targeting transporters for drug delivery to the brain: can we do better?
E Puris, G Fricker, M Gynther - Pharmaceutical Research, 2022 - Springer
Limited drug delivery to the brain is one of the major reasons for high failure rates of central
nervous system (CNS) drug candidates. The blood–brain barrier (BBB) with its tight …
nervous system (CNS) drug candidates. The blood–brain barrier (BBB) with its tight …
In vitro blood brain barrier models: An overview
E Jagtiani, M Yeolekar, S Naik, V Patravale - Journal of Controlled Release, 2022 - Elsevier
Understanding the composition and function of the blood brain barrier (BBB) enables the
development of novel, innovative techniques for administering central nervous system …
development of novel, innovative techniques for administering central nervous system …
Understanding drug delivery to the brain using liposome-based strategies: Studies that provide mechanistic insights are essential
F Juhairiyah, ECM de Lange - The AAPS Journal, 2021 - Springer
Brain drug delivery may be restricted by the blood-brain barrier (BBB), and enhancement by
liposome-based drug delivery strategies has been investigated. As access to the human …
liposome-based drug delivery strategies has been investigated. As access to the human …
Stem cell-based human blood–brain barrier models for drug discovery and delivery
S Aday, R Cecchelli, D Hallier-Vanuxeem… - Trends in …, 2016 - cell.com
The development of novel neuropharmaceuticals requires the evaluation of blood–brain
barrier (BBB) permeability and toxicity. Recent studies have highlighted differences in the …
barrier (BBB) permeability and toxicity. Recent studies have highlighted differences in the …
Why clinical modulation of efflux transport at the human blood–brain barrier is unlikely: the ITC evidence‐based position
JC Kalvass, JW Polli, DL Bourdet… - Clinical …, 2013 - Wiley Online Library
Drug interactions due to efflux transport inhibition at the blood–brain barrier (BBB) have
been receiving increasing scrutiny because of the theoretical possibility of adverse central …
been receiving increasing scrutiny because of the theoretical possibility of adverse central …