Vascular dysfunction in the pathogenesis of Alzheimer's disease—A review of endothelium-mediated mechanisms and ensuing vicious circles

LY Di Marco, A Venneri, E Farkas, PC Evans… - Neurobiology of …, 2015 - Elsevier
Late-onset dementia is a major health concern in the ageing population. Alzheimer's
disease (AD) accounts for the largest proportion (65–70%) of dementia cases in the older …

Neuroprotective effects of curcumin in cerebral ischemia: cellular and molecular mechanisms

L Subedi, BP Gaire - ACS Chemical Neuroscience, 2021 - ACS Publications
Despite being a major global health concern, cerebral ischemia/stroke has limited
therapeutic options. Tissue plasminogen activator (tPA) is the only available medication to …

Arsenic alters nitric oxide signaling similar to autism spectrum disorder and Alzheimer's disease-associated mutations

MK Tripathi, M Kartawy, S Ginzburg, H Amal - Translational Psychiatry, 2022 - nature.com
Epidemiological studies have proven that exposure to Arsenic (AS) leads to the
development of many neurological disorders. However, few studies have investigated its …

[HTML][HTML] High-fidelity imaging of amyloid-beta deposits with an ultrasensitive fluorescent probe facilitates the early diagnosis and treatment of Alzheimer's Disease

R Tao, N Wang, T Shen, Y Tan, Y Ren, W Wei… - Theranostics, 2022 - ncbi.nlm.nih.gov
Background: Imaging amyloid-beta (Aβ) deposits with high fidelity in naturally aging brains
is crucial for the early diagnosis of Alzheimer's disease (AD). However, this is impeded by …

The PERK-dependent molecular mechanisms as a novel therapeutic target for neurodegenerative diseases

W Rozpędek-Kamińska, N Siwecka… - International journal of …, 2020 - mdpi.com
Higher prevalence of neurodegenerative diseases is strictly connected with progressive
aging of the world population. Interestingly, a broad range of age-related …

Memory related molecular signatures: the pivots for memory consolidation and Alzheimer's related memory decline

M Kaushik, P Kaushik, S Parvez - Ageing Research Reviews, 2022 - Elsevier
Age-related cognitive decline is the major cause of concern due to its 70% more incidence
than dementia cases worldwide. Moreover, aging is also the major risk factor of Alzheimer's …

[HTML][HTML] Aberrant protein phosphorylation in Alzheimer disease brain disturbs pro-survival and cell death pathways

M Perluigi, E Barone, F Di Domenico… - Biochimica et Biophysica …, 2016 - Elsevier
Protein phosphorylation of serine, threonine, and tyrosine residues is one of the most
prevalent post-translational modifications fundamental in mediating diverse cellular …

Post-stroke impairment of the blood–brain barrier and perifocal vasogenic edema is alleviated by endovascular mesenchymal stem cell administration: modulation of …

A Datta, D Sarmah, H Kaur, A Chaudhary… - Molecular …, 2022 - Springer
Post-stroke edema and upregulation of aquaporin 4 (AQP4) water transport channels play a
significant role in the progression of stroke pathology and deteriorating stroke outcomes …

Vascular risk factors and Alzheimer's disease: blood-brain barrier disruption, metabolic syndromes, and molecular links

JT He, X Zhao, L Xu, CY Mao - Journal of Alzheimer's Disease, 2020 - content.iospress.com
Alzheimer's disease (AD) is a neurodegenerative disorder, marked by cortical and
hippocampal deposition of amyloid-β (Aβ) plaques and neurofibrillary tangles and cognitive …

Hypoxia-induced signaling activation in neurodegenerative diseases: targets for new therapeutic strategies

NK Jha, SK Jha, R Sharma, D Kumar… - Journal of …, 2018 - content.iospress.com
For the maintenance of cellular homeostasis and energy metabolism, an uninterrupted
supply of oxygen (O 2) is routinely required in the brain. However, under the impaired level …