Transient receptor potential channels as drug targets: from the science of basic research to the art of medicine

B Nilius, A Szallasi, DR Sibley - Pharmacological reviews, 2014 - Elsevier
The large Trp gene family encodes transient receptor potential (TRP) proteins that form
novel cation-selective ion channels. In mammals, 28 Trp channel genes have been …

[HTML][HTML] The impact of TRPV1 on cancer pathogenesis and therapy: a systematic review

L Li, C Chen, C Chiang, T Xiao, Y Chen… - … journal of biological …, 2021 - ncbi.nlm.nih.gov
The transient receptor potential cation channel subfamily V member 1 (TRPV1) is a
transmembrane protein that can be activated by various physical and chemical stimuli and is …

Lysophosphatidic acid directly activates TRPV1 through a C-terminal binding site

A Nieto-Posadas, G Picazo-Juárez, I Llorente… - Nature chemical …, 2012 - nature.com
Since 1992, there has been growing evidence that the bioactive phospholipid
lysophosphatidic acid (LPA), whose amounts are increased upon tissue injury, activates …

Expression and functionality of TRPV1 in breast cancer cells

LV Weber, K Al-Refae, G Wölk, G Bonatz… - … Cancer: Targets and …, 2016 - Taylor & Francis
Transient receptor potential (TRP) channels contribute to the regulation of intracellular
calcium, which can promote cancer hallmarks in cases of dysregulation of gene transcription …

TRPs in taste and chemesthesis

SD Roper - Mammalian Transient Receptor Potential (TRP) Cation …, 2014 - Springer
TRP channels are expressed in taste buds, nerve fibers, and keratinocytes in the oronasal
cavity. These channels play integral roles in transducing chemical stimuli, giving rise to …

TRP channels in digestive tract cancers

P Stokłosa, A Borgström, S Kappel… - International journal of …, 2020 - mdpi.com
Cancers of the digestive tract are among the most prevalent types of cancer. These types of
cancers are often diagnosed at a late stage, which results in a poor prognosis. Currently …

TRP channels in cancer: signaling mechanisms and translational approaches

M Marini, M Titiz, D Souza Monteiro de Araújo… - Biomolecules, 2023 - mdpi.com
Ion channels play a crucial role in a wide range of biological processes, including cell cycle
regulation and cancer progression. In particular, the transient receptor potential (TRP) family …

TRP channels and cancer: new targets for diagnosis and chemotherapy

G Santoni, V Farfariello - Endocrine, Metabolic & Immune …, 2011 - ingentaconnect.com
The Transient Receptor Potential (TRP) channels family consists of seven different
subfamilies, namely TRPC (Canonical), TRPV (Vanilloid), TRPM (Melastatin), TRPML …

Cannabinoids and omega-3/6 endocannabinoids as cell death and anticancer modulators

I Brown, MG Cascio, D Rotondo, RG Pertwee… - Progress in lipid …, 2013 - Elsevier
Cannabinoids-endocannaboids are possible preventatives of common diseases including
cancers. Cannabinoid receptors (CB1/2, TRPV1) are central components of the system …

Taste the pain: the role of TRP channels in pain and taste perception

EN Aroke, KL Powell-Roach, RB Jaime-Lara… - International journal of …, 2020 - mdpi.com
Transient receptor potential (TRP) channels are a superfamily of cation transmembrane
proteins that are expressed in many tissues and respond to many sensory stimuli. TRP …