Advancement of epigenetics in stroke

J Peng, D Ghosh, F Zhang, L Yang, J Wu… - Frontiers in …, 2022 - frontiersin.org
A wide plethora of intervention procedures, tissue plasminogen activators, mechanical
thrombectomy, and several neuroprotective drugs were reported in stroke research over the …

Epigenetic Responses to Nonchemical Stressors: Potential Molecular Links to Perinatal Health Outcomes

LA Eaves, CE Harrington, RC Fry - Current Environmental Health Reports, 2024 - Springer
Abstract Purpose of Review We summarize the recent literature investigating exposure to
four nonchemical stressors (financial stress, racism, psychosocial stress, and trauma) and …

Prenatal delta-9-tetrahydrocannabinol exposure is associated with changes in rhesus macaque DNA methylation enriched for autism genes

LE Shorey-Kendrick, VHJ Roberts, RJ D'Mello… - Clinical …, 2023 - Springer
Background With the growing availability of cannabis and the popularization of additional
routes of cannabis use beyond smoking, including edibles, the prevalence of cannabis use …

Prenatal Alcohol Exposure Impairs the Placenta–Cortex Transcriptomic Signature, Leading to Dysregulation of Angiogenic Pathways

C Sautreuil, M Lecointre, C Derambure… - International Journal of …, 2023 - mdpi.com
Although alcohol consumption during pregnancy is a major cause of behavioral and
learning disabilities, most FASD infants are late-or even misdiagnosed due to clinician's …

Placental Transcriptomic Signatures of Prenatal Phthalate Exposure and Identification of Placenta-Brain Genes Associated with the Effects of Phthalate Exposure on …

J Ren, Y Wang, Y Zhang, H Jin, J Cheng… - Environmental …, 2024 - ACS Publications
Prenatal exposure to phthalates may affect placental function and fetal development, but the
underlying mechanisms are unclear. The aim of our study was to explore the alterations in …

[HTML][HTML] Italian Guidelines for the diagnosis and treatment of Fetal Alcohol Spectrum Disorders: structural abnormalities

S Terracina, G Ferraguti, F Fanfarillo… - Rivista di …, 2024 - rivistadipsichiatria.it
Fetal Alcohol Spectrum Disorders (FASD) encompass a range of conditions caused by
prenatal alcohol consumption, leading to physical, behavioral, and learning challenges. It is …

Expression of placental CD146 is dysregulated by prenatal alcohol exposure and contributes in cortical vasculature development and positioning of vessel-associated …

C Sautreuil, M Lecointre, J Dalmasso… - Frontiers in Cellular …, 2024 - frontiersin.org
Recent data showed that prenatal alcohol exposure (PAE) impairs the “placenta–brain” axis
controlling fetal brain angiogenesis in human and preclinical models. Placental growth …

A multi‐omic approach identifies an autism spectrum disorder (ASD) regulatory complex of functional epimutations in placentas from children born preterm

AN Freedman, J Clark, LA Eaves, K Roell… - Autism …, 2023 - Wiley Online Library
Children born preterm are at heightened risk of neurodevelopmental impairments, including
Autism Spectrum Disorder (ASD). The placenta is a key regulator of neurodevelopmental …

Single-Cell Transcriptional Response of the Placenta to the Ablation of Caveolin-1: Insights into the Adaptive Regulation of Brain–Placental Axis in Mice

M Islam, SK Behura - Cells, 2024 - mdpi.com
Caveolin-1 (Cav1) is a major plasma membrane protein that plays important functions in
cellular metabolism, proliferation, and senescence. Mice lacking Cav1 show abnormal gene …

Advancing our knowledge of placental function and how it relates to the developing fetal brain

A Fox, B Hayes, E Doyle - Seminars in Fetal and Neonatal Medicine, 2024 - Elsevier
Perinatal medicine has made significant advancements in recent decades. This has
improved care and outcomes for infants. As we strive to improve neurodevelopmental …