E. Heart F. Blood Vessels and Endothelium VI. Pathogenesis and Pathophysiology in the
Intact Host A. Experimental Animal Models B. Spread of Virus within the Host C. Fever and …

Arboviruses cause millions of infections each year; however, only limited options are
available for treatment and pharmacological prevention. Mosquitoes are among the most …

Elevated circulating levels of chemokines have been reported in patients with dengue fever
and are proposed to contribute to the pathogenesis of dengue disease. To establish in vitro …

During the innate immune response against infections, Natural Killer (NK) cells are as
important effector cells as are Cytotoxic T lymphocytes (CTL) generated after antigenic …

Plaque assays for titrating dengue virus (DENV) are time-consuming and not suitable for
strains that do not plaque. Fluorescence-activated cell sorting (FACS) has been used to …

It is believed that the pathogenesis of dengue is generated by a deregulation of the
immunological response. Dengue virus-infected monocytes/macrophages are likely to …

Mononuclear phagocytes are considered to be main targets for Dengue Virus (DENV)
replication. These cells are activated after infection, producing proinflammatory mediators …

Monocytes/macrophages are important targets for dengue virus (DENV) replication; they
induce inflammatory mediators and are sources of viral dissemination in the initial phase of …

Dendritic cell-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) is
an important binding receptor for dengue virus (DENV) that recognizes N-glycosylation sites …

Approximately 500,000 people are hospitalized with severe dengue illness annually.
Antibody-dependent enhancement (ADE) of dengue virus (DENV) infection is believed to …