Most of the genetic information has been lost or transferred to the nucleus during the
evolution of mitochondria. Nevertheless, mitochondria have retained their own genome that …

Age is the main risk factor for a number of human diseases, including neurodegenerative
disorders such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral …

Microglia are critical in brain development and Alzheimer's disease (AD) etiology. Down
syndrome (DS) is the most common genetic developmental disorder and risk factor for AD …

Mitochondrial abnormalities have been identified as a central mechanism in multiple
neurodegenerative diseases and, therefore, the mitochondria have been explored as a …

In the last few years, increased emphasis has been devoted to understanding the
contribution of mitochondria-associated endoplasmic reticulum (ER) membranes (MAM) to …

Neurodegenerative disorders pose a significant health burden and imprint a debilitative
impact on the quality of life. Importantly, aging is intricately intertwined with the progression …

Alzheimer's disease (AD) is the most common cause of dementia worldwide and is
characterised pathologically by the accumulation of amyloid beta and tau protein …

Background Alzheimer's disease (AD) is the most prevalent form of dementia worldwide and
is characterized by progressive memory loss and cognitive impairment. Our understanding …

Mitochondrial respiratory deficiencies have been observed in numerous neurodegenerative
disorders, such as Alzheimer's and Parkinson's diseases. For decades, these reductions in …

Alzheimer's disease (AD) is a major cause of dementia in older adults and is fast becoming
a major societal and economic burden due to an increase in life expectancy. Age seems to …