Investigation of Potential Drug Targets Involved in Inflammation Contributing to Alzheimer's Disease Progression
Alzheimer's disease has become a major public health issue. While extensive research has
been conducted in the last few decades, few drugs have been approved by the FDA to treat …
been conducted in the last few decades, few drugs have been approved by the FDA to treat …
Investigation of potential drug targets for cholesterol regulation to treat Alzheimer's disease
Despite extensive research and seven approved drugs, the complex interplay of genes,
proteins, and pathways in Alzheimer's disease remains a challenge. This implies the …
proteins, and pathways in Alzheimer's disease remains a challenge. This implies the …
Sub-MIC vancomycin enhances the antibiotic tolerance of vancomycin-intermediate Staphylococcus aureus through downregulation of protein succinylation
Y Yang, L Tan, S He, B Hao, X Huang, Y Zhou… - Microbiological …, 2024 - Elsevier
Bacteria develop tolerance after transient exposure to antibiotics, and tolerance is a
significant driver of resistance. The purpose of this study is to evaluate the mechanisms …
significant driver of resistance. The purpose of this study is to evaluate the mechanisms …
Protein Interaction Network Analysis to Investigate Stress Response, Virulence, and Antibiotic Resistance Mechanisms in Listeria monocytogenes
Listeria monocytogenes is a deadly and costly foodborne pathogen that has a high fatality
rate in the elderly, pregnant women, and people with weakened immunity. It can survive …
rate in the elderly, pregnant women, and people with weakened immunity. It can survive …
Pathophysiology, current therapeutic options, vaccine candidates, and drug targets for human brucellosis
Brucellosis is an infectious disease caused by different species of Brucella bacteria. It is also
known as Malta fever, one of the neglected diseases that can cause infection in both …
known as Malta fever, one of the neglected diseases that can cause infection in both …
Inhibition of MurA Enzyme from Escherichia coli by Flavonoids and Their Synthetic Analogues
R Frlan, M Hrast, S Gobec - ACS omega, 2023 - ACS Publications
MurA catalyzes the first step of peptidoglycan (PG) biosynthesis and is a validated target for
the development of new antimicrobial agents. In this study, a library of 49 plant flavonoids …
the development of new antimicrobial agents. In this study, a library of 49 plant flavonoids …
Insights into Novel Arylazopyrazolo[1,5-a]pyrimidines as Promising MurA Inhibitors and Antibiofilm Candidates: Design, Synthesis, Antimicrobial Evaluation, and …
MurA is a pivotal target in antimicrobial therapy owing to its fundamental function in bacterial
cell wall production; inhibiting this enzyme not only disrupts cell integrity, leading to bacterial …
cell wall production; inhibiting this enzyme not only disrupts cell integrity, leading to bacterial …
Druggability Analysis of Protein Targets for Drug Discovery to Combat Listeria monocytogenes
R Hanes, Y Liu, Z Huang - Microorganisms, 2024 - mdpi.com
Extensive research has been conducted to identify key proteins governing stress responses,
virulence, and antimicrobial resistance, as well as to elucidate their interactions within …
virulence, and antimicrobial resistance, as well as to elucidate their interactions within …
[HTML][HTML] Insights into Novel Arylazopyrazolo [1, 5-a] pyrimidines as Promising MurA Inhibitors and Antibiofilm Candidates: Design, Synthesis, Antimicrobial Evaluation …
MurA is a pivotal target in antimicrobial therapy owing to its fundamental function in bacterial
cell wall production; inhibiting this enzyme not only disrupts cell integrity, leading to bacterial …
cell wall production; inhibiting this enzyme not only disrupts cell integrity, leading to bacterial …
Identification of potential inhibitors against Escherichia coli Mur D enzyme to combat rising drug resistance: an in-silico approach
V Gaur, N Kumar, A Vyas, D Chowdhury… - Journal of …, 2023 - Taylor & Francis
Indiscriminate use of anti-microbial agents has resulted in the inception, frequency, and
spread of antibiotic resistance among targeted bacterial pathogens and the commensal …
spread of antibiotic resistance among targeted bacterial pathogens and the commensal …