Mitochondria are essential for the activity, function and viability of eukaryotic cells and
mitochondrial dysfunction is involved in the pathogenesis of acute kidney injury (AKI) and …

Loss of normal kidney function affects more than 10% of the population and contributes to
morbidity and mortality. Kidney diseases are currently treated with immunosuppressive …

In a diabetic milieu high levels of reactive oxygen species (ROS) are induced. This
contributes to the vascular complications of diabetes. Recent studies have shown that ROS …

Albuminuria is the hallmark of both primary and secondary proteinuric glomerulopathies,
including focal segmental glomerulosclerosis (FSGS), obesity-related nephropathy, and …

Globally, diabetes is the leading cause of chronic kidney disease and end-stage renal
disease, which are major risk factors for cardiovascular disease and death. Despite this …

Microvascular and metabolic physiology are tightly linked. This Perspective reviews
evidence that 1) the relationship between hyperglycemia and microvascular dysfunction …

Although diabetic kidney disease (DKD) is the most common cause of end-stage kidney
disease worldwide, the pathogenic mechanisms are poorly understood. There is increasing …

There has been an alarming increase in the prevalence of obesity in people with type 1
diabetes in recent years. Although obesity has long been recognized as a major risk factor …

Acute kidney injury (AKI) and chronic kidney disease (CKD) are interconnected conditions,
and CKD is projected to become the fifth leading global cause of death by 2040. New …

Diabetic kidney disease (DKD) is the leading cause of end-stage renal disease (ESRD), with
prevalence increasing at an alarming rate worldwide and today, there are no known cures …