Circadian rhythms and sleep are fundamental biological processes integral to human
health. Their disruption is associated with detrimental physiological consequences …

A brain organoid is a self-organizing three-dimensional tissue derived from human
embryonic stem cells or pluripotent stem cells and is able to simulate the architecture and …

Importance The associations between muscle strength and cognitive outcomes have
sparked interest in interventions that increase muscle strength for prevention of dementia …

Background Alzheimer's disease (AD) is the most frequently occurring type of dementia.
Concurrently, inadequate sleep has been recognized as a public health epidemic. Notably …

Background Visual impairment and interventions to preserve vision may impact dementia
risk. Thus, we aimed to explore the associations of cataract and cataract surgery with the risk …

Failed proteostasis is a well-documented feature of Alzheimer's disease, particularly,
reduced protein degradation and clearance. However, the contribution of failed proteostasis …

Background The association between body mass index (BMI) and Alzheimer's disease (AD)
remains controversial. Genetic and environmental factors are now considered contributors to …

Alzheimer disease (AD) is the most common type of dementia characterized by the
progressive cognitive and social decline. Clinical drug targets have heavily focused on the …

Preliminary evidence suggests that neighborhood environments, such as socioeconomic
disadvantage, pedestrian and physical activity infrastructure, and availability of …

Sleep disorders affect many people worldwide and can accompany neurodegenerative and
psychiatric diseases. Sleep may be altered before the clinical manifestations of some of …