Nanopore sequencing is a rapidly maturing technology delivering long reads in real time on
a portable instrument at low cost. Not surprisingly, the community has rapidly taken up this …

The maturation of high-throughput short-read sequencing technology over the past two
decades has shaped the way genomes are studied. Recently, single-molecule, long-read …

The primary structure of a protein consists of a sequence of amino acids and is a key factor
in determining how a protein folds and functions. However, conventional methods for …

Despite advances in sequencing, structural variants (SVs) remain difficult to reliably detect
due to the short read length (< 300 bp) of 2nd generation sequencing. Not only do the reads …

Electrochemistry studies charge transfer and related processes at various microscopic
structures (atomic steps, islands, pits and kinks on electrodes), and mesoscopic materials …

Recent advances in top-down mass spectrometry enabled identification of intact proteins,
but this technology still faces challenges. For example, top-down mass spectrometry suffers …

Biological computation involves the design and development of computational techniques
inspired by natural biota. On the other hand, computational biology involves the …

Provided herein are methods and systems pertaining to sequencing units of analytes using
nanopores. In general, arresting constructs are used to modify an analyte such that the …

This paper introduces a high-speed mixed-signal readout array in 130-nm CMOS for the
amplification and digitization of picoampere-range signals. Its design is inspired by the …

In polymer sequencing with a nanopore multiple discriminators may be used to distinguish
among more monomers than usual. This leads to a proposal to sequence peptides using a …