Aging is a complex process that results in loss of the ability to reattain homeostasis following
stress, leading, thereby, to increased risk of morbidity and mortality. Many factors contribute …

Ageing is affected by both genetic and non-genetic factors. Here, we review the chromatin-
based epigenetic changes that occur during ageing, the role of chromatin modifiers in …

Lines of evidence from several studies have shown that increases in life expectancy are now
accompanied by increased disability rate. The expanded lifespan of the aging population …

The senescence programme is implicated in diverse biological processes, including
embryogenesis, tissue regeneration and repair, tumorigenesis, and ageing. Although in vivo …

Background Ageing is the inevitable time-dependent decline in physiological organ function
that eventually leads to death. Age is a major risk factor for many of the most common …

The program of cellular senescence is involved in both the G1 and G2 phase of the cell
cycle, limiting G1/S and G2/M progression respectively, and resulting in prolonged cell cycle …

Nutrition plays a key role in many aspects of health and dietary imbalances are major
determinants of chronic diseases including cardiovascular disease, obesity, diabetes and …

Aging is associated with the accumulation of cellular damage over the course of a lifetime.
This process is promoted in large part by reactive oxygen species (ROS) generated via …

The lifespan extension induced by 40% caloric restriction (CR) in rodents is accompanied by
postponement of disease, preservation of function, and increased stress resistance. Whether …

As regulators of bioenergetics in the cell and the primary source of endogenous reactive
oxygen species (ROS), dysfunctional mitochondria have been implicated for decades in the …