The soil saprophyte, Burkholderia pseudomallei, is the causative agent of melioidosis, a
disease endemic in South East Asia and northern Australia. Exposure to B. pseudomallei by …

The type III secretion system (T3SS) is a virulence apparatus used by many Gram-negative
pathogenic bacteria to cause infections. Pathogens utilizing a T3SS are responsible for …

Burkholderia pseudomallei is a Gram-negative intracellular pathogen and the causative
agent of melioidosis, a severe disease of both humans and animals. Melioidosis is an …

Cells of the innate immune system continuously patrol the extracellular environment for
potential microbial threats that are to be neutralized by phagocytosis and delivery to …

Highlights•Burkholderia pseudomallei (BPS) possess a variety of virulence factors that
facilitate survival at different stages of intracellular infection in a variety of cell types.•At the …

The Gram-negative proteobacteria genus Burkholderia encompasses multiple bacterial
species that are pathogenic to humans and other vertebrates. Two pathogenic species of …

The aerobic, Gram-negative motile bacillus, Burkholderia pseudomallei is a facultative
intracellular bacterium causing melioidosis, a critical disease of public health importance …

Symbiotic associations impact and are impacted by their surrounding ecosystem. The
association between Burkholderia bacteria and the soil amoeba Dictyostelium discoideum is …

Shigella rely entirely on the action of a single type three secretion system (T3SS) to support
cellular invasion of colonic epithelial cells and to circumvent host immune responses. The …

Gram-negative bacteria utilize the type III secretion system (T3SS) to inject effector proteins
into the host cell cytoplasm, where they subvert cellular functions and assist pathogen …