CAD (Carbamoyl-phosphate synthetase 2, Aspartate transcarbamoylase, and
Dihydroorotase) is a multifunctional protein that participates in the initial three speed-limiting …

The spread of infectious diseases is rampant. The emergence of new infections, the
irrational use of antibiotics in medicine and their widespread use in agriculture contribute to …

American tegumentary leishmaniasis is a vector-borne parasitic disease caused by
Leishmania protozoans. Innate immune cells undergo long-term functional reprogramming …

Innate immune cells can undergo long-term functional reprogramming after certain
infections, a process called trained immunity (TI). Here, we focus on antigens of Leishmania …

Foot-and-mouth disease virus (FMDV) is a single-stranded picornavirus that causes
economically devastating disease in even-hooved animals. There has been little research …

The fate of Leishmania infection can be strongly influenced by the host genetic background.
In this work, we describe gene expression modulation of the immune system based on dual …

Background Cells of the innate immune system undergo long-term functional
reprogramming in response to Bacillus Calmette-Guérin (BCG) exposure via a process …

Circadian rhythms are recurring variations of physiology with a period of~ 24 h, generated
by circadian clocks located throughout the body. Studies have shown a circadian regulation …

Leishmania spp. depend on effective macrophage infection to establish and develop in
mammalian hosts. Both metacyclic promastigotes and amastigotes are able to infect host …

Interleukin-32 (IL-32) has several immune regulatory properties, which have driven its
investigation in the context of various diseases. IL-32 expression is reported to be induced in …