Remodeling of tumor microenvironment by cellular senescence and immunosenescence in cervical cancer

Y He, Y Qiu, X Yang, G Lu, SS Zhao - Seminars in Cancer Biology, 2024 - Elsevier
Cellular senescence is a response to various stress signals, which is characterized by stable
cell cycle arrest, alterations in cellular morphology, metabolic reprogramming and …

Targeting Anoikis Resistance as a Strategy for Cancer Therapy

Y Wang, S Cheng, JS Fleishman, J Chen, H Tang… - Drug Resistance …, 2024 - Elsevier
Anoikis, known as matrix detachment-induced apoptosis or detachment-induced cell death,
is crucial for tissue development and homeostasis. Cancer cells develop means to evade …

Regulation and tumor‐suppressive function of the miR‐379/miR‐656 (C14MC) cluster in cervical cancer

S Srinath, PV Jishnu, VK Varghese, V Shukla… - Molecular …, 2024 - Wiley Online Library
Cervical cancer (CC) is a key contributor to cancer‐related mortality in several countries.
The identification of molecular markers and the underlying mechanism may help improve …

Bisphenol A exposure modulates reproductive and endocrine system, mitochondrial function and cellular senescence in female adult rats: a hallmarks of polycystic …

NB Prabhu, D Adiga, SP Kabekkodu, SK Bhat… - Environmental …, 2022 - Elsevier
Bisphenol A (BPA) mimics estrogen and consequently suspected to be detrimental to female
reproductive system. Biomonitoring confirms the BPA burden in body leading to a complex …

DOC2B is a negative regulator of Wnt/β-catenin signaling pathway in cervical cancer

D Adiga, S Bhat, S Chakrabarty… - Pharmacological Research, 2022 - Elsevier
DOC2B is a ubiquitously expressed isoform of the double C-2 protein family that requires Ca
2+ for most of its physiological functions. Initial findings have indicated that DOC2B …

Double C-2 like domain beta (DOC2B) induces calcium dependent oxidative stress to promote lipotoxicity and mitochondrial dysfunction for its tumor suppressive …

D Adiga, S Bhat, V Shukla, HV Shah… - Free Radical Biology …, 2023 - Elsevier
Mitochondria are biosynthetic and bioenergetic organelles that regulate many biological
processes, including metabolism, oxidative stress, and cell death. Cervical cancer (CC) cells …

A Novel Role for DOC2B in Ameliorating Palmitate-Induced Glucose Uptake Dysfunction in Skeletal Muscle Cells via a Mechanism Involving β-AR Agonism and …

J Hwang, R Balakrishnan, E Oh, R Veluthakal… - International Journal of …, 2023 - mdpi.com
Diet-related lipotoxic stress is a significant driver of skeletal muscle insulin resistance (IR)
and type 2 diabetes (T2D) onset. β2-adrenergic receptor (β-AR) agonism promotes insulin …

Comprehensive analysis of the exocytosis pathway genes in cervical cancer

S Eswaran, D Adiga, N Khan, S Sriharikrishnaa… - The American Journal of …, 2022 - Elsevier
Background Cervical cancer (CC) is the fourth most common gynecological malignancy
globally. This suggests the need for improved markers for prognosis, better understanding of …

Goji berry (Lycium barbarum) inhibits the proliferation, adhesion, and migration of oral cancer cells by inhibiting the ERK, AKT, and CyclinD cell signaling pathways …

A Sanghavi, A Srivatsa, D Adiga, A Chopra… - …, 2023 - pmc.ncbi.nlm.nih.gov
Background: Lycium barbarum (L. barbarum), popularly referred to as Goji berry, is a
promising herb known for its powerful anti-antioxidant, antibacterial, and anti-inflammatory …

Integrated bioinformatic analysis to understand the association between phthalate exposure and breast cancer progression

NG Khan, S Eswaran, D Adiga… - Toxicology and Applied …, 2022 - Elsevier
Phthalates have been extensively used as plasticizers while manufacturing plastic-based
consumer products. Estradiol mimicking properties and association studies suggest …