The pathogenesis of primary biliary cholangitis: a comprehensive review

A Lleo, PSC Leung, GM Hirschfield… - Seminars in liver …, 2020 - thieme-connect.com
Primary biliary cholangitis (PBC) is a chronic cholestatic liver disease characterized by
autoimmune destruction of small to medium size intrahepatic bile ducts. The etiology of PBC …

Primary biliary cholangitis: a comprehensive overview

A Lleo, S Marzorati, JM Anaya, ME Gershwin - Hepatology international, 2017 - Springer
Primary biliary cholangitis (PBC) is an autoimmune liver disease characterized by biliary
destruction, progressive cholestasis, and potentially liver cirrhosis. Patients develop a well …

[HTML][HTML] Primary biliary cirrhosis: Clinical and laboratory criteria for its diagnosis

VI Reshetnyak - World Journal of Gastroenterology: WJG, 2015 - ncbi.nlm.nih.gov
Primary biliary cirrhosis (PBC) is a chronic progressive cholestatic granulomatous, and
destructive inflammatory lesion of small intralobular and septal bile ducts, which is likely to …

Protection against oxidative stress mediated by the Nrf2/Keap1 axis is impaired in Primary Biliary Cholangitis

U Wasik, M Milkiewicz, A Kempinska-Podhorodecka… - Scientific Reports, 2017 - nature.com
In response to oxidative stress, nuclear factor (erythroid-derived 2)-like2 (Nrf2) induces
expression of cytoprotective genes. The Nrf2 pathway is controlled by microRNAs and Kelch …

Primary biliary cholangitis: molecular pathogenesis perspectives and therapeutic potential of natural products

Y Zhao, S Wei, L Chen, X Zhou, X Ma - Frontiers in Immunology, 2023 - frontiersin.org
Primary biliary cirrhosis (PBC) is a chronic cholestatic immune liver disease characterized
by persistent cholestasis, interlobular bile duct damage, portal inflammation, liver fibrosis …

Primary biliary cholangitis: A tale of epigenetically-induced secretory failure?

PM Rodrigues, MJ Perugorria, A Santos-Laso… - Journal of …, 2018 - Elsevier
Primary biliary cholangitis (PBC) is a chronic cholestatic liver disease associated with
autoimmune-related destruction of small to medium size intrahepatic bile ducts. The …

The role of epigenetics in primary biliary cholangitis

A Gerussi, EM Paraboschi, C Cappadona… - International Journal of …, 2022 - mdpi.com
Primary Biliary Cholangitis (PBC) is a rare autoimmune disease of the liver, affecting mostly
females. There is evidence that epigenetic changes have a pathogenic role in PBC …

Circulating microRNAs: emerging biomarkers of liver disease

M Arrese, A Eguchi, AE Feldstein - Seminars in liver disease, 2015 - thieme-connect.com
Development of reliable, noninvasive biomarkers that allow for diagnosis, risk stratification,
and monitoring of disease changes over time or in response to specific therapies represents …

[HTML][HTML] Role of circulating microRNAs in liver diseases

SH Loosen, F Schueller, C Trautwein… - World journal of …, 2017 - ncbi.nlm.nih.gov
MicroRNAs (miRNAs) are small RNAs regulate gene expression by inhibiting the turnover of
their target mRNAs. In the last years, it became apparent that miRNAs are released into the …

[HTML][HTML] MicroRNAs as possible biomarkers for diagnosis and prognosis of hepatitis B-and C-related-hepatocellular-carcinoma

S Fiorino, ML Bacchi-Reggiani, M Visani… - World journal of …, 2016 - ncbi.nlm.nih.gov
Aim of the present review is to summarize the current knowledge about the potential
relationship between miRNAs and hepatitis B virus (HBV)-hepatitis C virus (HCV) related …