Human organoids in basic research and clinical applications

XY Tang, S Wu, D Wang, C Chu, Y Hong… - Signal transduction and …, 2022 - nature.com
Organoids are three-dimensional (3D) miniature structures cultured in vitro produced from
either human pluripotent stem cells (hPSCs) or adult stem cells (AdSCs) derived from …

2020 ESC Guidelines on sports cardiology and exercise in patients with cardiovascular disease: The Task Force on sports cardiology and exercise in patients with …

A Pelliccia, S Sharma, S Gati, M Bäck… - European heart …, 2021 - academic.oup.com
or therapeutic medical strategies. However, the ESC Guidelines do not override in any way
whatsoever the individual responsibility of health professionals to make appropriate and …

Genomic frontiers in congenital heart disease

SU Morton, D Quiat, JG Seidman… - Nature Reviews …, 2022 - nature.com
The application of next-generation sequencing to study congenital heart disease (CHD) is
increasingly providing new insights into the causes and mechanisms of this prevalent birth …

Genetic basis for congenital heart disease: revisited: a scientific statement from the American Heart Association

ME Pierpont, M Brueckner, WK Chung, V Garg… - Circulation, 2018 - Am Heart Assoc
This review provides an updated summary of the state of our knowledge of the genetic
contributions to the pathogenesis of congenital heart disease. Since 2007, when the initial …

Management of pregnancy in patients with complex congenital heart disease: a scientific statement for healthcare professionals from the American Heart Association

MM Canobbio, CA Warnes, J Aboulhosn… - Circulation, 2017 - Am Heart Assoc
Today, most female children born with congenital heart disease will reach childbearing age.
For many women with complex congenital heart disease, carrying a pregnancy carries a …

Diagnosis and treatment of fetal cardiac disease: a scientific statement from the American Heart Association

MT Donofrio, AJ Moon-Grady, LK Hornberger… - Circulation, 2014 - Am Heart Assoc
Background—The goal of this statement is to review available literature and to put forth a
scientific statement on the current practice of fetal cardiac medicine, including the diagnosis …

2018 ESC guidelines for the management of cardiovascular diseases during pregnancy: the task force for the management of cardiovascular diseases during …

V Regitz-Zagrosek, JW Roos-Hesselink… - European heart …, 2018 - academic.oup.com
not override in any way whatsoever the individual responsibility of health professionals to
make appropriate and accurate decisions in consideration of each patient's health condition …

Neurodevelopmental outcomes in children with congenital heart disease: evaluation and management: a scientific statement from the American Heart Association

BS Marino, PH Lipkin, JW Newburger, G Peacock… - Circulation, 2012 - Am Heart Assoc
Background—The goal of this statement was to review the available literature on
surveillance, screening, evaluation, and management strategies and put forward a scientific …

Distinct genetic architectures for syndromic and nonsyndromic congenital heart defects identified by exome sequencing

A Sifrim, MP Hitz, A Wilsdon, J Breckpot, SHA Turki… - Nature …, 2016 - nature.com
Congenital heart defects (CHDs) have a neonatal incidence of 0.8–1%(refs.,). Despite
abundant examples of monogenic CHD in humans and mice, CHD has a low absolute …

Genetics of congenital heart disease: the glass half empty

AC Fahed, BD Gelb, JG Seidman… - Circulation research, 2013 - Am Heart Assoc
Congenital heart disease (CHD) is the most common congenital anomaly in newborn
babies. Cardiac malformations have been produced in multiple experimental animal …