Visualization of the cellular heterogeneity and spatial architecture of the tumor
microenvironment (TME) is becoming increasingly important to understand mechanisms of …

Next-generation DNA sequencing technology has dramatically advanced clinical oncology
through the identification of therapeutic targets and molecular biomarkers, leading to the …

Neutrophils are abundant immune cells in the circulation and frequently infiltrate tumors in
substantial numbers. However, their precise functions in different cancer types remain …

Tissue localization is a critical determinant of T cell immunity. CD8+ T cells are contact-
dependent killers, which requires them to physically be within the tissue of interest to kill …

The spatial distribution of lymphocyte clones within tissues is critical to their development,
selection, and expansion. We have developed spatial transcriptomics of variable, diversity …

In the past decade, single-cell technologies have revealed the heterogeneity of the tumor-
immune microenvironment at the genomic, transcriptomic, and proteomic levels and have …

Spatial resolution of the T cell repertoire is essential for deciphering cancer-associated
immune dysfunction. Current spatially resolved transcriptomic technologies are unable to …

The immune-specialized environment of the healthy brain is tightly regulated to prevent
excessive neuroinflammation. However, after cancer development, a tissue-specific conflict …

T cells are at the center of cancer immunology because of their ability to recognize mutations
in tumor cells and directly mediate cancer cell killing. Immunotherapies to rejuvenate …

Abstract Profiling the T-Cell Receptor (TCR) repertoire is establishing as a potent approach
to investigate autologous and treatment-induced antitumor immune response. Technical and …