The biologically relevant coordination chemistry of iron and nitric oxide: electronic structure and reactivity
Nitric oxide (NO) is an important signaling molecule that is involved in a wide range of
physiological and pathological events in biology. Metal coordination chemistry, especially …
physiological and pathological events in biology. Metal coordination chemistry, especially …
Synthetic analogues relevant to the structure and function of zinc enzymes
G Parkin - Chemical Reviews, 2004 - ACS Publications
Zinc is essential to all forms of life, 1-4 with an average adult human containing ca. 3 g of
zinc. 5 For example, zinc is indispensable for effective growth and development, has …
zinc. 5 For example, zinc is indispensable for effective growth and development, has …
Principles of mononucleating and binucleating ligand design
AL Gavrilova, B Bosnich - Chemical reviews, 2004 - ACS Publications
Although multimetallic complexes were known early in the development of modern
coordination chemistry, it is only over the past 30 years that special attention has been …
coordination chemistry, it is only over the past 30 years that special attention has been …
The catalytic mechanisms of binuclear metallohydrolases
Binuclear metallohydrolases are a structurally diverse group of enzymes that use binuclear
metal ion centers to catalyze the hydrolysis of amides and esters of carboxylic and …
metal ion centers to catalyze the hydrolysis of amides and esters of carboxylic and …
Purple acid phosphatase: a journey into the function and mechanism of a colorful enzyme
Purple acid phosphatases (PAPs) catalyze the hydrolysis of a wide range of
phosphomonoester and amide substrates. These enzymes have been identified and …
phosphomonoester and amide substrates. These enzymes have been identified and …
Copper (II), zinc (II) and nickel (II) complexes as nuclease mimetics
D Desbouis, IP Troitsky, MJ Belousoff, L Spiccia… - Coordination Chemistry …, 2012 - Elsevier
The manipulation of phosphate ester linkages is very important in the chemistry of life. Cells
possess highly evolved enzymatic machinery to make and break these linkages, which are …
possess highly evolved enzymatic machinery to make and break these linkages, which are …
An Unprecedented FeIII(μ-OH)ZnII Complex that Mimics the Structural and Functional Properties of Purple Acid Phosphatases
This communication reports the synthesis and X-ray structure of the first mixed-valence
FeIIIZnII complex containing the FeIII (μ-OH) ZnII structural unit. Based on the structure …
FeIIIZnII complex containing the FeIII (μ-OH) ZnII structural unit. Based on the structure …
Spectroscopic and mechanistic studies of dinuclear metallohydrolases and their biomimetic complexes
An enhanced understanding of the metal ion binding and active site structural features of
phosphoesterases such as the glycerophosphodiesterase from Enterobacter aerogenes …
phosphoesterases such as the glycerophosphodiesterase from Enterobacter aerogenes …
Electronic Structure and Spectro-Structural Correlations of FeIIIZnII Biomimetics for Purple Acid Phosphatases: Relevance to DNA Cleavage and Cytotoxic Activity
Purple acid phosphatases (PAPs) are a group of metallohydrolases that contain a dinuclear
FeIIIMII center (MII= Fe, Mn, Zn) in the active site and are able to catalyze the hydrolysis of a …
FeIIIMII center (MII= Fe, Mn, Zn) in the active site and are able to catalyze the hydrolysis of a …
Nickel complexes of carboxylate-containing polydentate ligands as models for the active site of urease
H Carlsson, M Haukka, A Bousseksou… - Inorganic …, 2004 - ACS Publications
Two new carboxylate-containing polydentate ligands have been synthesized, the symmetric
ligand 2, 6-bis [N-(N-(carboxylmethyl)-N-((1-methylimidazol) methyl) amine) methyl]-4 …
ligand 2, 6-bis [N-(N-(carboxylmethyl)-N-((1-methylimidazol) methyl) amine) methyl]-4 …