Macrophages are one of the immune populations frequently found in colorectal tumors and
high macrophage infiltration has been associated with both better and worst prognosis …

Background Lipopolysaccharide (LPS) is widely recognized as a potent activator of
monocytes/macrophages, and its effects include an altered production of key mediators …

Some of the most successful pathogens of human, such as Mycobacterium tuberculosis
(Mtb), HIV, and Leishmania donovani not only establish chronic infections but also remain a …

Objective: Macrophages are immune cells, capable to remodel the extracellular matrix,
which can harbor extracellular DNA incorporated into neutrophil extracellular traps (NETs) …

Antigen-nonspecific inflammation appears to contribute to postischemic brain injury.
Because there is a breach in the integrity of the blood-brain barrier after stroke, the immune …

Objective Tofacitinib, which is a Janus kinase (JAK) inhibitor, has shown clinical effects in
the treatment of rheumatoid arthritis. JAKs are important kinases in lymphocyte …

Esophageal squamous cell carcinoma (ESCC) accounts for the main esophageal cancer
(ESCA) type, which is also associated with the greatest malignant grade and low survival …

In this study, we investigated the role of a transcription factor, PU. 1, in the regulation of
CD80 and CD86 expression in dendritic cells (DCs). A chromatin immunoprecipitation assay …

Dengue virus (DENV) causes 400 million infections annually and is one of several viruses
that can cause viral hemorrhagic fever, which is characterized by uncontrolled immune …

Eosinophils play critical roles in the maintenance of homeostasis in innate and adaptive
immunity. Although primarily known for their roles in parasitic infections and the …